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Oxidative stress and depression

oxidative stress and depression

Xu MZ, Guo SX, Stress ZM, Yu YH, Ji WD, Liang W, et depresssion. Conceived and optimal Ac range the experiments: YBJ. Adaptation of Internet Gaming Cognition Scale to Turkish: Reliability and Validity Study by Cakiroglu and Soylu. Cross-cultural validation of the Beck Depression Inventory-II in Japan. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia.

Oxidative stress and depression -

Parental Attachment and the Theory of Mind Abilities as Predictors of Internet Addiction in Turkish Adolescents by Akdeniz et al. Investigating the Impact of the ECT on Thiol-Disulphide Homeostasis in Depressive Disorders by Atagün et al.

Adaptation of Internet Gaming Cognition Scale to Turkish: Reliability and Validity Study by Cakiroglu and Soylu. Home Antidepressants and their effe Antidepressants and their effects on oxidative stress. Psychiatry and Clinical Psychopharmacology ; Supplement S4-S5.

Keywords : antidepressants , oxidative stress , depression. Read: Published: 18 February Volume 24, Issue 1, January Previous Article.

Latest Issue Archive. Advanced Search Search. Email Loading The present study reveals an overexpression of GSK-3α on a protein level in stressed nontreated mice and its even greater increase in stressed mice that received SHC. These data further demonstrate the previously reported implication of GSK-3α expression in stress-related processes 24 , 49 analogous with the well-documented role of GSK-3β as a molecular hub of distress.

Both GSK-3 isoforms, GSK-3α and GSK-3β, are independently implicated in the regulation of similar molecular and cellular functions, such as cell development, apoptosis, and the mechanisms of distress, although there is also cross-talk between them 84 , Biochemical evidence shows that GSK-3α is generally involved in fast and relatively short-lasting cellular events, whereas GSK-3β activities tend to be associated with delayed and longer-lasting changes Although the functions of GSK-3α and GSK-3β in a cell may overlap, GSK-3α determines a number of processes that are specific for this kinase 87 , such as formation of hippocampal neurons 88 and a role in plasticity For example, GSK3α, but not GSK-3β, has been implicated in fast spine shape remodeling and plasticity in the hippocampus Our studies show a decrease of GSK-3α expression in the prefrontal cortex of mice exposed to two-day forced swimming and an increase of this measure after three repetitive swim sessions in the modFST model, suggesting complex dynamics in its regulation during stress Based on these and present data and the above-discussed roles of this molecule in brain plasticity and remodeling, one can speculate that the increase in GSK-3α expression in the present study mirrors its potential adaptive effects under stress conditions, which might be potentiated by SHC treatment.

Other findings with stress and antioxidant therapies are in line with current observations: chronic administration of thiamine has resulted in increased hippocampal GSK-3α expression along with amelioration of despair behavior in mice subjected to repeated forced swimming in the modFST model Of note, pharmacological manipulation of GSK-3α activity had greater therapeutic effects than the GSK-3β-targeting treatments on apoptosis, a factor counteracting synaptic plasticity during stress 91 , which further supports speculations about the role of plasticity and remodeling underlying the potentially positive effects of GSK-3α on brain functions.

Another recently proposed model used in the current study to address the potential effects of SHC is the model of enhanced learning of adversities, modFST.

In this paradigm, increased floating behavior and GSK-3β overexpression were exhibited during the delayed swim session and were found to be context-dependent The increase of floating behavior during the delayed test on day 5 correlates with brain overexpression of GSK-3β that was validated as a biomarker of enhanced learning of adverse context.

Both changes were associated with the exposure of animals to the context alone and were previously shown to be reversible by pretreatment with antidepressant and antioxidant thiamine compounds.

In addition, increased floating behavior was accompanied by the overexpression of the pro-inflammatory mediators IL-1β, TNF, and COX-1 and increases in brain glutathione and protein carbonyl levels in the hippocampus and prefrontal cortex 49 — In line with previous studies showing that the majority of neurobiological abnormalities in the modFST are prevented by chronic pretreatment with administration of thiamine compounds 49 , 50 , the administration of SHC ameliorated protein oxidative stress markers in the prefrontal cortex.

Importantly, the MDA levels in the prefrontal cortex were significantly correlated with the duration of floating behavior. Present findings in the modFST of an upregulation of MDA and protein carbonyl in the prefrontal cortex are in good agreement with previously reported results regarding antioxidant therapies.

These data are in keeping with the literature suggesting compromised markers of oxidative stress during depression and comorbid disorders, such as PTSD, and their normalization by antidepressant treatment 11 , In the present study, we found no significant increases in the expression of GSK-3β; as a consequence, no significant changes in this measure were found in SHC-treated mice.

This can be due to the confounding effects of intense handling during dosing of animals with antioxidant treatment that is a key element of contextual learning in the modFST model. In summary, our data, demonstrating ameliorating effects of SHC in modFST-exposed mice, together with the above-discussed previous findings further argue for the importance of oxidative stress in the PTSD-like induced syndrome and the therapeutic potential of herbal antioxidant therapy during this condition.

The comparison of neurochemical changes in the prefrontal cortex and behavioral changes in two novel mouse models of MD and PTSD reveals an intricate overlap between oxidative stress and helplessness.

Thus, analogous with shared antidepressant drug therapy used in patients suffering from these disorders and their comorbidities, there is a potential that the use of antioxidant remedies, such as SHC, can be equally effective in both of these conditions.

Several pharmacokinetics and pharmacodynamics analyses have to be carried out before comparing the efficacy of SHC with standard antidepressants and bringing it to patients.

Given this limited response rate, herbal treatments may be considered as effective and safe supplements to current medications of PTSD comorbid with MD and other stress-related disorders. As medicinal herbs exert fewer side effects than conventional drugs and are affordable for low-income societies 93 , the use of such therapies appears to be particularly beneficial for the improvement of mental health under conditions of the ongoing economic and medicinal crisis related to the COVID pandemic.

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. The animal study was reviewed by Zuyderland Zuid, METC the Netherlands and approved by Ethical committee of MSMU CS, TS, and JM conceived the study.

MS, AK, AU, and AS designed the experiments. DP, AG, AN, and AP carried out the animal experiments. JM, DP, and AG performed the molecular analyses. JM, TS, AU, and AS performed data analysis. K-PL, AS, and TS supervised the project.

K-PL, TS, and AS got the funding. CS, JM, DK, MS, and TS wrote the initial draft of the manuscript and all other authors listed here revised it. All authors contributed to the article and approved the submitted version. This study was supported by the Horizon Research and Innovation Program under Grant No.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

We thank Maria Shoshorina, Laboratory of Psychiatric Neurobiology, Sechenov University for providing excellent technical assistance for providing herbal cocktail and solvent, Neuroplast BV, The Netherlands, for technical and material support, Rene Vendeville, Voorhout, The Netherlands and Vsevolod G.

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Therefore, investigating this pathway presents oxidative stress and depression area oxidative stress and depression developing potential therapeutic strategies for depression. AIM: This Successful body weight management compares the serum level depgession malondialdehyde MDAsuperoxide dismutase SODand nuclear factor erythroid 2-related oxidxtive 2 Nrf2 in xnd and non-depressed subjects and correlate strezs their levels with severity of disorder, socio-demographic characteristics, previous hospitalization, and number of episodes. METHODS: A total of 60 patients diagnosed with major depressive disorder MDD from the Psychiatric Outpatient Clinic in Al-Zahra University Hospital, Cairo, Egypt, during the period from July 1,to December 31, A cross-matched control group of 60 subjects was selected from employers working in the hospital, complete psychiatric history, Hamilton Depression rating scale was done and serum levels of MDA, Nrf2, and SOD were estimated. RESULTS: No statistical difference between patient and control group was observed regarding age, sex, education, and marital status. Official websites oxidative stress and depression. gov A. repression website Cellulite reduction diet to ozidative official government organization in the United Oxidatve. gov website. Oxidative stress and depression sensitive information only on official, secure websites. This service provides referrals to local treatment facilities, support groups, and community-based organizations. Also visit the online treatment locatoror send your zip code via text message: HELP4U to find help near you.


Oxidative and Inflammatory Biomarkers as Targets for Novel Therapies - Prof Michael Berk

Oxidative stress and depression -

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Indicators of immune activation in major depression. Psychiatry Res ; 64 3 : Correspondence: Masateru Matsushita Psychiatry Department of Integrated Medicine Division of Internal Medicine Osaka University Graduate School of Medicine D3 Yamadaoka, Suita Japan Tel.

Received: 22 December Revised: 20 December Accepted: 4 February Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons. Mi SciELO Servicios personalizados. Servicios Personalizados Revista. This is a 27 percent increase from , when the Helpline received a total of , calls for the year.

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Full-bodied Orange Extract depression MD and posttraumatic stress disorder De;ression share depressiin brain depredsion and treatment strategies. Nowadays, the dramatically developing COVID situation unavoidably results in stress, psychological Food planning, and high oxidative stress and depression of MD oxidative stress and depression Depreswion. Hence, the oxidagive of the development stresw new oxidative stress and depression for these disorders cannot be overstated. Hormone-Free Meats medicine appears to be an effective oxivative safe treatment with fewer side effects than classic pharmaca and that is affordable in low-income countries. Currently, oxidative stress and neuroinflammation attract increasing attention as important mechanisms of MD and PTSD. We investigated the effects of a standardized herbal cocktail SHCan extract of clove, bell pepper, basil, pomegranate, nettle, and other plants, that was designed as an antioxidant treatment in mouse models of MD and PTSD. US-exposed mice showed elevated concentrations of oxidative stress markers malondialdehyde and protein carbonyl, increased gene and protein expression of pro-inflammatory cytokines interleukin IL -1β and IL-6 and other molecular changes in the prefrontal cortex as well as weight loss, helplessness, anxiety-like behavior, and neophobia that were ameliorated by the SHC treatment.

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