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Caloric intake and dietary restrictions

Caloric intake and dietary restrictions

Provided by the Cashew nut allergies Nature SharedIt content-sharing initiative. Ketones an may inhibit the Cashew nut allergies of ad because Cqloric cells Diabetes and chronic stress management effectively obtain energy from ketones. Rietary Next Cashew nut allergies Research? Lifestyle management: standards of medical care in diabetes CAS PubMed Google Scholar Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala V, Portero-Otin M, Barja G, Pamplona R: Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain. The paper concludes by providing a summary and suggestions for future research.

Caloric intake and dietary restrictions -

Weight management and loss seems like a difficult health measure to get right, but keep a close eye on the number of calories you consume can help…. It seems as though every month there is another dieting fad, that promises to melt away the pounds over night and keep you trim.

Researchers say bariatric surgery can help with weight loss, but it can also help improve cognitive functions including memory. Researchers say running can help with weight loss but only in the short term. This form of exercise does have other health benefits from maintaining….

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Medical News Today. Health Conditions Health Products Discover Tools Connect. Is 1, calories a day enough? Medically reviewed by Kim Chin, RD , Nutrition — By Zawn Villines — Updated on November 29, Weight loss Safety Meal ideas FAQ Summary A restrictive diet requires a person to reduce their daily intake, for example, to 1, calories.

Weight loss. Meal ideas. Frequently asked questions. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.

We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles.

You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Ovarian tissue freezing may help delay, and even prevent menopause. RSV vaccine errors in babies, pregnant people: Should you be worried? Scientists discover biological mechanism of hearing loss caused by loud noise — and find a way to prevent it.

How gastric bypass surgery can help with type 2 diabetes remission. Atlantic diet may help prevent metabolic syndrome. Related Coverage. What to know about the calorie diet. Medically reviewed by Natalie Butler, R. Counting calories for weight loss. Many studies have shown that obese and overweight people who lose weight by dieting can improve their health.

But scientists still have much to learn about how calorie restriction and fasting affect people who are not overweight, including older adults.

They also don't know whether these eating patterns are safe or even doable in the long run. In short, there's not enough evidence to recommend any such eating regimen to the public.

Calorie restriction is a consistent pattern of reducing average daily caloric intake, while fasting regimens primarily focus on the frequency of eating. The fasting diet may or may not involve a restriction in the intake of calories during non-fasting times.

There are a variety of fasting diets, sometimes called "intermittent fasting. More animal research has been done on calorie restriction than on fasting. In some experiments, calorie restriction is also a form of fasting because the lab animals consume all their daily allotted food within hours and go many more hours without any food.

In these studies, when rodents and other animals were given 10 percent to 40 percent fewer calories than usual but provided with all necessary nutrients, many showed extension of lifespan and reduced rates of several diseases, especially cancers.

But, some studies did not show this benefit, and in some mouse strains, calorie restriction shortened lifespan rather than extending it. In the worm C. elegans , a fasting diet increased lifespan by 40 percent. A study with fruit flies found that calorie restriction—but not intermittent fasting—was associated with living longer.

One study of male mice found that lifelong alternate-day fasting increased longevity, mainly by delaying cancer occurrence rather than slowing other aging processes.

Two National Institute on Aging NIA -supported studies in rhesus monkeys sought to find out whether the benefits of calorie restriction are seen in longer-lived species. In both studies, the monkeys were kept on a calorie-restriction diet 30 percent fewer calories than for monkeys in the control groups for more than 20 years.

Although there were differences between the two studies—including monkey breed and type of food—both provided evidence that calorie restriction reduced the incidence of age-related conditions, such as cancer, heart disease, and diabetes. One study found an extension of lifespan, while the other did not.

Many of the monkeys are still alive, so the full impact of calorie restriction on their maximum lifespan has yet to be determined. Some study results suggest that calorie restriction may have health benefits for humans, but more research is needed before we understand its long-term effects.

There are no data in humans on the relationship between calorie restriction and longevity. Some people have voluntarily practiced extreme degrees of calorie restriction over many years in the belief that it will extend lifespan or preserve health.

Studies on these individuals have found markedly low levels of risk factors for cardiovascular disease and diabetes. The studies have also found many other physiologic effects whose long-term benefits and risks are uncertain, as well as reductions in sexual interest and the ability to maintain body temperature in cold environments.

These people generally consume a variety of nutritional supplements, which limits knowing which effects are due to calorie restriction versus other factors. To conduct a more rigorous study of calorie restriction in humans, NIA supported a pioneering clinical trial called Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy CALERIE.

In CALERIE, young and middle-aged, normal-weight or moderately overweight adults were randomly divided into two groups. People in the experimental group were told to follow a calorie-restriction diet for 2 years, while those in the control group followed their usual diet.

The study was designed to have participants in the experimental group eat 25 percent fewer calories per day than they had regularly consumed before the study.

Although they did not meet this target, they reduced their daily caloric intake by 12 percent and maintained, on average, a 10 percent loss in body weight over 2 years. A follow-up study 2 years after the intervention ended found that participants had sustained much of this weight loss.

It's important to note that calorie-restriction regimens are not starvation diets. The weight loss achieved with calorie restriction in the CALERIE trial resulted in body weights within the normal or overweight range. Compared to participants in the control group, those in the calorie-restriction group had reduced risk factors lower blood pressure and lower cholesterol for age-related diseases such as diabetes , heart disease , and stroke.

They also showed decreases in some inflammatory factors and thyroid hormones. There is some evidence that lower levels of these measures are associated with longer lifespan and diminished risk for age-related diseases.

Moreover, in the calorie-restricted individuals, no adverse effects and some favorable ones were found on quality of life, mood, sexual function , and sleep. Calories matter, but counting them is not at all necessary to lose weight.

Here are 7 scientifically proven ways to lose fat on "autopilot. Yo-yo dieting is the pattern of losing weight, regaining it and then dieting again. This article examines 10 reasons why yo-yo dieting is bad for you.

When limiting your calorie intake, it's important to choose nutritious low-calorie foods. Here are 42 healthy foods that are very low in calories. Discover which diet is best for managing your diabetes. Getting enough fiber is crucial to overall gut health.

Let's look at some easy ways to get more into your diet:. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 5 Ways Restricting Calories Can Be Harmful.

By Alina Petre, MS, RD NL — Updated on January 30, How we vet brands and products Healthline only shows you brands and products that we stand behind. Our team thoroughly researches and evaluates the recommendations we make on our site.

To establish that the product manufacturers addressed safety and efficacy standards, we: Evaluate ingredients and composition: Do they have the potential to cause harm? Fact-check all health claims: Do they align with the current body of scientific evidence?

Assess the brand: Does it operate with integrity and adhere to industry best practices? We do the research so you can find trusted products for your health and wellness. Read more about our vetting process. Was this helpful? People trying to lose weight often restrict the number of calories they eat.

Your Calorie Needs, Explained. Your body requires calories to function and uses them to sustain three main processes 1 : Basal metabolic rate BMR : This refers to the number of calories needed to cover your basic functions, including the proper functioning of your brain, kidneys, heart, lungs and nervous system.

Digestion: Your body uses a certain number of calories to digest and metabolize the foods you eat. This is also known as the thermic effect of food TEF. Physical activity: This refers to the number of calories needed to fuel your everyday tasks and workouts.

However, restricting calories too much may harm your health in the following 5 ways. It Can Lower Your Metabolism. Summary: Severely restricting your calories can decrease your metabolism and cause you to lose muscle mass. It Can Cause Fatigue and Nutrient Deficiencies. Calorie-restricted diets may limit other nutrients too, including: Protein: Not eating enough protein-rich foods like meat, fish, dairy, beans, peas, lentils, nuts and seeds may cause muscle loss, hair thinning and brittle nails Calcium: Not eating enough calcium-rich foods like dairy, leafy greens, calcium-set tofu and fortified milks may reduce bone strength and increase the risk of fractures Biotin and thiamine: A low intake of whole grains, legumes, eggs, dairy, nuts and seeds may limit your intake of these two B vitamins, potentially resulting in muscle weakness, hair loss and scaly skin 27 , Vitamin A: Not eating enough vitamin A-rich foods like organ meat, fish, dairy, leafy greens or orange-colored fruits and vegetables may weaken your immune system and lead to permanent eye damage Magnesium: An insufficient intake of magnesium-rich whole grains, nuts and leafy greens may cause fatigue, migraines, muscle cramps and abnormal heart rhythms

BMC Reetrictions volume 21Article number: Cite restrictuons article. Metrics Plant-based fuel sources. However, the Cashew nut allergies regimens have Caloric intake and dietary restrictions to intakw thoroughly compared. The primary outcome was the change in body mass index BMI. The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health education sessions during the trial. A total of participants were analyzed.

Caloric intake and dietary restrictions -

Comfort A: Effect of delayed and resumed growth on the longevity of a fish Lebistes reticulates, Peters in captivity. Google Scholar. Lawler DF, Larson BT, Ballam JM, Smith GK, Biery DN, Evans RH, Greeley EH, Segre M, Stowe HD, Kealy RD: Diet restriction and ageing in the dog: major observations over two decades.

Br J Nutr. Imai S: SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Curr Opin Clin Nutr Metab Care. Vaquero A, Reinberg D: Calorie restriction and the exercise of chromatin.

Genes Dev. Vendelbo MH, Nair KS: Mitochondrial longevity pathways. Biochim Biophys Acta. Fadini GP, Ceolotto G, Pagnin E, de Kreutzenberg S, Avogaro A: At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways. Aging Cell. Carrillo AE, Flouris AD: Caloric restriction and longevity: effects of reduced body temperature.

Ageing Res Rev. Kyrylenko S, Baniahmad A: Sirtuin family: a link to metabolic signaling and senescence. Curr Med Chem. Smoliga JM, Baur JA, Hausenblas HA: Resveratrol and health - A comprehensive review of human clinical trials.

Mol Nutr Food Res. Agarwal B, Baur JA: Resveratrol and life extension. Ann N Y Acad Sci. Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G: Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

Varady KA, Hellerstein MK: Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP: Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake.

Proc Natl Acad Sci USA. Abete P, Testa G, Galizia G, Mazzella F, Della Morte D, de Santis D, Calabrese C, Cacciatore F, Gargiulo G, Ferrara N, Rengo G, Sica V, Napoli C, Rengo F: Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart.

Crandall DL, Feirer RP, Griffith DR, Beitz DC: Relative role of caloric restriction and exercise training upon susceptibility to isoproterenol-induced myocardial infarction in male rats. Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C: Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin J Gerontol A Biol Sci Med Sci.

Deruisseau KC, Kavazis AN, Judge S, Murlasits Z, Deering MA, Quindry JC, Lee Y, Falk DJ, Leeuwenburgh C, Powers SK: Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise. Antioxid Redox Signal. Holloszy JO: Mortality rate and longevity of food-restricted exercising male rats: a reevaluation.

J Appl Physiol. Huffman DM, Moellering DR, Grizzle WE, Stockard CR, Johnson MS, Nagy TR: Effect of exercise and calorie restriction on biomarkers of aging in mice. Am J Physiol Regul Integr Comp Physiol. Horska A, Brant LJ, Ingram DK, Hansford RG, Roth GS, Spencer RG: Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats.

Am J Physiol. Iwasaki K, Gleiser CA, Masoro EJ, McMahan CA, Seo EJ, Yu BP: The influence of dietary protein source on longevity and age-related disease processes of Fischer rats. J Gerontol. Shimokawa I, Higami Y, Yu BP, Masoro EJ, Ikeda T: Influence of dietary components on occurrence of and mortality due to neoplasms in male F rats.

Aging Milano. CAS Google Scholar. Khorakova M, Deil Z, Khausman D, Matsek K: Effect of carbohydrate-enriched diet and subsequent food restriction on life prolongation in Fischer male rats.

Fiziol Zh. Kubo C, Johnson BC, Gajjar A, Good RA: Crucial dietary factors in maximizing life span and longevity in autoimmune-prone mice. J Nutr. Pamplona R, Barja G: Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

Sanz A, Caro P, Sanchez JG, Barja G: Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage. Sanz A, Gomez J, Caro P, Barja G: Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage.

J Bioenerg Biomembr. Sarri KO, Higgins S, Kafatos AG: Are religions "healthy"? A review of religious recommendations on diet and lifestyle. Ecology, Culture, Nutrition, Health and Disease. Trepanowski JF, Bloomer RJ: The impact of religious fasting on human health. Nutr J.

PubMed PubMed Central Google Scholar. Edwards IJ, Rudel LL, Terry JG, Kemnitz JW, Weindruch R, Cefalu WT: Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. Kayo T, Allison DB, Weindruch R, Prolla TA: Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys.

Lane MA, Ball SS, Ingram DK, Cutler RG, Engel J, Read V, Roth GS: Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Lane MA, Ingram DK, Roth GS: Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk.

Toxicol Sci. Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J: Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.

Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R: Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC: Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans.

Annu Rev Med. Merry BJ: Molecular mechanisms linking calorie restriction and longevity. Int J Biochem Cell Biol. Jung KJ, Lee EK, Kim JY, Zou Y, Sung B, Heo HS, Kim MK, Lee J, Kim ND, Yu BP, Chung HY: Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.

Inflamm Res. Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR: Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. Swoap SJ: Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction.

Am J Physiol Heart Circ Physiol. Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA: Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Wang Z, Masternak MM, Al-Regaiey KA, Bartke A: Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T, Shima K: Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus?.

Diabetes Res Clin Pract. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME: Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab. Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ: Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria.

Hyun DH, Emerson SS, Jo DG, Mattson MP, de Cabo R: Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Nandy K: Effects of controlled dietary restriction on brain-reactive antibodies in sera of aging mice.

Mech Ageing Dev. Weindruch R, Walford RL, Fligiel S, Guthrie D: The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. Pitsikas N, Carli M, Fidecka S, Algeri S: Effect of life-long hypocaloric diet on age-related changes in motor and cognitive behavior in a rat population.

Neurobiol Aging. Colman RJ, Beasley TM, Allison DB, Weindruch R: Attenuation of sarcopenia by dietary restriction in rhesus monkeys.

Keenan KP, Ballam GC, Dixit R, Soper KA, Laroque P, Mattson BA, Adams SP, Coleman JB: The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, disease and toxicology. Pugh TD, Oberley TD, Weindruch R: Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.

Cancer Res. Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E, CALERIE Pennington Team: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO, the Washington University School of Medicine CALERIE Group: Calorie restriction or exercise: effects on coronary heart disease risk factors.

A randomized, controlled trial. Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO: Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E, Pennington CALERIE Team: Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.

Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C: Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res. Larson-Meyer DE, Newcomer BR, Heilbronn LK, Volaufova J, Smith SR, Alfonso AJ, Lefevre M, Rood JC, Williamson DA, Ravussin E, Pennington CALERIE Team: Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.

Obesity Silver Spring. Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E, Pennington CALERIE team: Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Redman LM, Veldhuis JD, Rood J, Smith SR, Williamson D, Ravussin E, for the Pennington CALERIE Team: The effect of caloric restriction interventions on growth hormone secretion in non-obese men and women.

Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO: Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.

Arch Intern Med. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group: Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial.

Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO, Washington University School of Medicine CALERIE Group: Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss.

Verdery RB, Walford RL: Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Walford RL, Mock D, MacCallum T, Laseter JL: Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives.

Walford RL, Mock D, Verdery R, MacCallum T: Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. Fontana L, Meyer TE, Klein S, Holloszy JO: Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.

Fontana L, Klein S, Holloszy JO, Premachandra BN: Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.

J Clin Endocrinol Metab. Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L: Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol. Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, Curb JD, Suzuki M: Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.

Holloszy JO, Fontana L: Caloric restriction in humans. Crujeiras AB, Parra D, Abete I, Martinez JA: A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects.

Free Radic Res. Crujeiras AB, Parra D, Goyenechea E, Abete I, Martinez JA: Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction. Eur J Nutr. Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R: The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation.

Skrha J, Kunesova M, Hilgertova J, Weiserova H, Krizova J, Kotrlikova E: Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients.

Physiol Res. Galassetti PR, Nemet D, Pescatello A, Rose-Gottron C, Larson J, Cooper DM: Exercise, caloric restriction, and systemic oxidative stress. J Investig Med. Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML: Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men.

Witte AV, Fobker M, Gellner R, Knecht S, Floel A: Caloric restriction improves memory in elderly humans.

Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V: Inhibitory effect of a two day fast on reactive oxygen species ROS generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.

Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A: Biomarkers of oxidative damage in human disease. Clin Chem. Larson-Meyer DE, Redman L, Heilbronn LK, Martin CK, Ravussin E: Caloric restriction with or without exercise: the fitness versus fatness debate.

Med Sci Sports Exerc. Silverman NE, Nicklas BJ, Ryan AS: Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. Calcif Tissue Int. Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP: Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial.

Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, Hellerstein MK: Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. J Lipid Res. Descamps O, Riondel J, Ducros V, Roussel AM: Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting.

Duan W, Guo Z, Jiang H, Ware M, Mattson MP: Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M: Cardioprotection by intermittent fasting in rats.

Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP: Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. Pedersen CR, Hagemann I, Bock T, Buschard K: Intermittent feeding and fasting reduces diabetes incidence in BB rats.

Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB: Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p FEBS Lett. Wan R, Camandola S, Mattson MP: Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats.

Mattson MP, Wan R: Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem.

Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E: Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Johnson JB, Laub DR, John S: The effect on health of alternate day calorie restriction: eating less and more than needed on alternate days prolongs life.

Med Hypotheses. Heilbronn LK, Civitarese AE, Bogacka I, Smith SR, Hulver M, Ravussin E: Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting.

Obes Res. Halberg N, Henriksen M, Soderhamn N, Stallknecht B, Ploug T, Schjerling P, Dela F: Effect of intermittent fasting and refeeding on insulin action in healthy men.

Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Telljohann R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP: Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.

Free Radic Biol Med. Hubert MF, Laroque P, Gillet JP, Keenan KP: The effects of diet, ad Libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats. Djuric Z, Lewis SM, Lu MH, Mayhugh M, Naegeli L, Tang N, Hart RW: Effect of varying caloric restriction levels on female rat growth and 5-hydroxymethyl-2'-deoxyuridine in DNA.

Simpson SJ, Raubenheimer D: Caloric restriction and aging revisited: the need for a geometric analysis of the nutritional bases of aging.

Segall PE, Timiras PS: Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging. Ooka H, Segall PE, Timiras PS: Histology and survival in age-delayed low-tryptophan-fed rats. Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M: Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance.

Orentreich N, Matias JR, DeFelice A, Zimmerman JA: Low methionine ingestion by rats extends life span.

Richie JP, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA: Methionine restriction increases blood glutathione and longevity in F rats. Richie JP, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, Zimmerman JA: Tissue glutathione and cysteine levels in methionine-restricted rats.

Zimmerman JA, Malloy V, Krajcik R, Orentreich N: Nutritional control of aging. Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G: Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.

Caro P, Gomez J, Lopez-Torres M, Sanchez I, Naudi A, Jove M, Pamplona R, Barja G: Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala V, Portero-Otin M, Barja G, Pamplona R: Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.

Ruiz MC, Ayala V, Portero-Otin M, Requena JR, Barja G, Pamplona R: Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.

Moskovitz J, Bar-Noy S, Williams WM, Requena J, Berlett BS, Stadtman ER: Methionine sulfoxide reductase MsrA is a regulator of antioxidant defense and lifespan in mammals. Hidiroglou N, Gilani GS, Long L, Zhao X, Madere R, Cockell K, Belonge B, Ratnayake WM, Peace R: The influence of dietary vitamin E, fat, and methionine on blood cholesterol profile, homocysteine levels, and oxidizability of low density lipoprotein in the gerbil.

McCarty MF, Barroso-Aranda J, Contreras F: The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Ibrahim WH, Habib HM, Jarrar AH, Al Baz SA: Effect of Ramadan fasting on markers of oxidative stress and serum biochemical markers of cellular damage in healthy subjects.

Ann Nutr Metab. Hallak MH, Nomani MZ: Body weight loss and changes in blood lipid levels in normal men on hypocaloric diets during Ramadan fasting. Lamine F, Bouguerra R, Jabrane J, Marrakchi Z, Ben Rayana MC, Ben Slama C, Gaigi S: Food intake and high density lipoprotein cholesterol levels changes during ramadan fasting in healthy young subjects.

Tunis Med. el Ati J, Beji C, Danguir J: Increased fat oxidation during Ramadan fasting in healthy women: an adaptative mechanism for body-weight maintenance. Maislos M, Khamaysi N, Assali A, Abou-Rabiah Y, Zvili I, Shany S: Marked increase in plasma high-density-lipoprotein cholesterol after prolonged fasting during Ramadan.

Ziaee V, Razaei M, Ahmadinejad Z, Shaikh H, Yousefi R, Yarmohammadi L, Bozorgi F, Behjati MJ: The changes of metabolic profile and weight during Ramadan fasting.

Singapore Med J. Aksungar FB, Eren A, Ure S, Teskin O, Ates G: Effects of intermittent fasting on serum lipid levels, coagulation status and plasma homocysteine levels.

Aksungar FB, Topkaya AE, Akyildiz M: Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. Lamri-Senhadji MY, El Kebir B, Belleville J, Bouchenak M: Assessment of dietary consumption and time-course of changes in serum lipids and lipoproteins before, during and after Ramadan in young Algerian adults.

Salehi M, Neghab M: Effects of fasting and a medium calorie balanced diet during the holy month Ramadan on weight, BMI and some blood parameters of overweight males. Pak J Biol Sci. Husain R, Duncan MT, Cheah SH, Ch'ng SL: Effects of fasting in Ramadan on tropical Asiatic Moslems.

Ramadan J, Telahoun G, Al-Zaid NS, Barac-Nieto M: Responses to exercise, fluid, and energy balances during Ramadan in sedentary and active males.

Ramadan J: Does fasting during Ramadan alter body composition, blood constituents and physical performance?. Med Princ Pract. Sarraf-Zadegan N, Atashi M, Naderi GA, Baghai AM, Asgary S, Fatehifar MR, Samarian H, Zarei M: The effect of fasting in Ramadan on the values and interrelations between biochemical, coagulation and hematological factors.

Ann Saudi Med. Chamsi-Pasha H, Ahmed WH: The effect of fasting in Ramadan on patients with heart disease. Saudi Med J. Fakhrzadeh H, Larijani B, Sanjari M, Baradar-Jalili R, Amini MR: Effect of Ramadan fasting on clinical and biochemical parameters in healthy adults.

Perk G, Ghanem J, Aamar S, Ben-Ishay D, Bursztyn M: The effect of the fast of Ramadan on ambulatory blood pressure in treated hypertensives. J Hum Hypertens. Chaouachi A, Coutts AJ, Wong del P, Roky R, Mbazaa A, Amri M, Chamari K: Haematological, inflammatory, and immunological responses in elite judo athletes maintaining high training loads during Ramadan.

Appl Physiol Nutr Metab. Kassab SE, Abdul-Ghaffar T, Nagalla DS, Sachdeva U, Nayar U: Serum leptin and insulin levels during chronic diurnal fasting. Asia Pac J Clin Nutr. Roky R, Iraki L, HajKhlifa R, Lakhdar Ghazal N, Hakkou F: Daytime alertness, mood, psychomotor performances, and oral temperature during Ramadan intermittent fasting.

Roky R, Chapotot F, Benchekroun MT, Benaji B, Hakkou F, Elkhalifi H, Buguet A: Daytime sleepiness during Ramadan intermittent fasting: polysomnographic and quantitative waking EEG study. J Sleep Res. Afifi ZE: Daily practices, study performance and health during the Ramadan fast.

J R Soc Health. Kadri N, Tilane A, El Batal M, Taltit Y, Tahiri SM, Moussaoui D: Irritability during the month of Ramadan. Psychosom Med. Iraki L, Bogdan A, Hakkou F, Amrani N, Abkari A, Touitou Y: Ramadan diet restrictions modify the circadian time structure in humans.

A study on plasma gastrin, insulin, glucose, and calcium and on gastric pH. Leiper JB, Molla AM, Molla AM: Effects on health of fluid restriction during fasting in Ramadan. Eur J Clin Nutr. Meckel Y, Ismaeel A, Eliakim A: The effect of the Ramadan fast on physical performance and dietary habits in adolescent soccer players.

Eur J Appl Physiol. Bogdan A, Bouchareb B, Touitou Y: Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans?.

Life Sci. Haghdoost AA, Poorranjbar M: The interaction between physical activity and fasting on the serum lipid profile during Ramadan.

Papadaki A, Vardavas C, Hatzis C, Kafatos A: Calcium, nutrient and food intake of Greek Orthodox Christian monks during a fasting and non-fasting week. Public Health Nutr.

Sarri KO, Tzanakis NE, Linardakis MK, Mamalakis GD, Kafatos AG: Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity. BMC Public Health. Sarri KO, Linardakis MK, Bervanaki FN, Tzanakis NE, Kafatos AG: Greek Orthodox fasting rituals: a hidden characteristic of the Mediterranean diet of Crete.

Sarri KO, Kafatos AG, Higgins S: Is religious fasting related to iron status in Greek Orthodox Christians?. Sarri K, Linardakis M, Codrington C, Kafatos A: Does the periodic vegetarianism of Greek Orthodox Christians benefit blood pressure?.

Prev Med. Dwyer JT: Health aspects of vegetarian diets. Key TJ, Appleby PN, Rosell MS: Health effects of vegetarian and vegan diets.

Proc Nutr Soc. Bloomer RJ, Kabir MM, Canale RE, Trepanowski JF, Marshall KE, Farney TM, Hammond KG: Effect of a 21 day Daniel Fast on metabolic and cardiovascular disease risk factors in men and women.

Lipids Health Dis. Bloomer RJ, Kabir MM, Trepanowski JF, Canale RE, Farney TM: A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women. Nutr Metab Lond. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Richard J Bloomer.

JFT, REC, KEM, MMK, and RJB were all involved in the review of relevant literature pertaining to this topic and in the writing and editing of this manuscript. All authors read and approved the final manuscript. Open Access This article is published under license to BioMed Central Ltd.

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Abstract Considerable interest has been shown in the ability of caloric restriction CR to improve multiple parameters of health and to extend lifespan. Introduction Since the seminal work of McCay et al.

Caloric Restriction and Animals Rodents and primates are the two most commonly studied species in CR animal trials. Caloric Restriction and Humans It is difficult to definitively answer whether or not CR prolongs human life because of the ethical and logistical limitations of research design.

Caloric Restriction combined with Exercise Animals A number of studies have examined whether the addition of exercise to a CR regimen CE augments any of the health-promoting benefits caused by CR alone. Humans Several CE studies have involved human subjects [ 61 , 64 , 66 , 67 , 84 , 89 — 91 ].

Alternate-Day Fasting and Animals ADF consists of alternating hour periods of ad libitum intake "feast period" and partial or complete restriction of caloric consumption "fast period".

Alternate-Day Fasting and Humans Of the ADF trials that have been performed, relatively few have used human subjects.

Religious Fasting Several religions place one or more of the following restrictions on food consumption: 1 the types of foods permitted for consumption in general or during particular times of the year; 2 the time of day when food consumption is permitted; and 3 food preparation [ 34 ].

Ramadan During the holy month of Ramadan, all healthy adult Muslims are forbidden from consuming any food or water from sunrise Sahur to sunset Iftar. Greek Orthodox There are three principal fasting periods for Greek Orthodox Christians. Daniel Fast A popular fast practiced by many Christians and Jews is the Daniel Fast, based on the Biblical story of Daniel , in which Daniel resolved not to defile himself with the royal food and wine, and he asked the chief official for permission to provide to him and his three friends nothing but vegetables to eat and water to drink for 10 days.

Overall Summary and Conclusions CR has been demonstrated to extend the maximal lifespan of a diverse group of species. Abbreviations ADF: alternate-day fasting ASUI: Asthma Symptom Utility Index BDNF: brain-derived neurotrophic factor CALERIE: Comprehensive Assessment of Long Term Effects of Reducing Caloric Intake CE: caloric restriction combined with exercise CR: caloric restriction DR: dietary restriction FEV 1 : forced expiratory volume HDL: high density lipoprotein LDL: low density lipoprotein MDA: malondialdehyde MI: myocardial infarction mini-AQLQ: mini-Asthma Quality of Life Questionnaire PEF: Peak Expiratory Flow.

References McCay CM, Crowell MF, Maynard LA: The effect of retarded growth upon the length of life span and upon the ultimate body size. discussion CAS PubMed Google Scholar Canto C, Auwerx J: Caloric restriction, SIRT1 and longevity.

CAS PubMed PubMed Central Google Scholar Min KJ, Flatt T, Kulaots I, Tatar M: Counting calories in Drosophila diet restriction. PubMed Google Scholar Comfort A: Effect of delayed and resumed growth on the longevity of a fish Lebistes reticulates, Peters in captivity.

Google Scholar Lawler DF, Larson BT, Ballam JM, Smith GK, Biery DN, Evans RH, Greeley EH, Segre M, Stowe HD, Kealy RD: Diet restriction and ageing in the dog: major observations over two decades. CAS PubMed Google Scholar Imai S: SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.

CAS PubMed PubMed Central Google Scholar Vaquero A, Reinberg D: Calorie restriction and the exercise of chromatin. CAS PubMed PubMed Central Google Scholar Vendelbo MH, Nair KS: Mitochondrial longevity pathways.

CAS PubMed PubMed Central Google Scholar Fadini GP, Ceolotto G, Pagnin E, de Kreutzenberg S, Avogaro A: At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways.

CAS PubMed Google Scholar Carrillo AE, Flouris AD: Caloric restriction and longevity: effects of reduced body temperature.

PubMed Google Scholar Kyrylenko S, Baniahmad A: Sirtuin family: a link to metabolic signaling and senescence. CAS PubMed Google Scholar Smoliga JM, Baur JA, Hausenblas HA: Resveratrol and health - A comprehensive review of human clinical trials.

CAS PubMed Google Scholar Agarwal B, Baur JA: Resveratrol and life extension. CAS PubMed Google Scholar Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G: Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

CAS PubMed Google Scholar Varady KA, Hellerstein MK: Alternate-day fasting and chronic disease prevention: a review of human and animal trials. CAS PubMed Google Scholar Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP: Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake.

CAS PubMed PubMed Central Google Scholar Abete P, Testa G, Galizia G, Mazzella F, Della Morte D, de Santis D, Calabrese C, Cacciatore F, Gargiulo G, Ferrara N, Rengo G, Sica V, Napoli C, Rengo F: Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart.

CAS PubMed Google Scholar Crandall DL, Feirer RP, Griffith DR, Beitz DC: Relative role of caloric restriction and exercise training upon susceptibility to isoproterenol-induced myocardial infarction in male rats.

CAS PubMed Google Scholar Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C: Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin CAS PubMed PubMed Central Google Scholar Deruisseau KC, Kavazis AN, Judge S, Murlasits Z, Deering MA, Quindry JC, Lee Y, Falk DJ, Leeuwenburgh C, Powers SK: Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise.

CAS PubMed Google Scholar Holloszy JO: Mortality rate and longevity of food-restricted exercising male rats: a reevaluation. CAS PubMed Google Scholar Huffman DM, Moellering DR, Grizzle WE, Stockard CR, Johnson MS, Nagy TR: Effect of exercise and calorie restriction on biomarkers of aging in mice.

CAS PubMed Google Scholar Horska A, Brant LJ, Ingram DK, Hansford RG, Roth GS, Spencer RG: Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats. CAS PubMed Google Scholar Iwasaki K, Gleiser CA, Masoro EJ, McMahan CA, Seo EJ, Yu BP: The influence of dietary protein source on longevity and age-related disease processes of Fischer rats.

CAS PubMed Google Scholar Shimokawa I, Higami Y, Yu BP, Masoro EJ, Ikeda T: Influence of dietary components on occurrence of and mortality due to neoplasms in male F rats.

CAS Google Scholar Khorakova M, Deil Z, Khausman D, Matsek K: Effect of carbohydrate-enriched diet and subsequent food restriction on life prolongation in Fischer male rats.

CAS PubMed Google Scholar Kubo C, Johnson BC, Gajjar A, Good RA: Crucial dietary factors in maximizing life span and longevity in autoimmune-prone mice. CAS PubMed Google Scholar Pamplona R, Barja G: Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

CAS PubMed Google Scholar Sanz A, Caro P, Sanchez JG, Barja G: Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage. CAS PubMed Google Scholar Sanz A, Gomez J, Caro P, Barja G: Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage.

CAS PubMed Google Scholar Sarri KO, Higgins S, Kafatos AG: Are religions "healthy"? Google Scholar Trepanowski JF, Bloomer RJ: The impact of religious fasting on human health.

PubMed PubMed Central Google Scholar Edwards IJ, Rudel LL, Terry JG, Kemnitz JW, Weindruch R, Cefalu WT: Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans.

CAS PubMed Google Scholar Kayo T, Allison DB, Weindruch R, Prolla TA: Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. CAS PubMed PubMed Central Google Scholar Lane MA, Ball SS, Ingram DK, Cutler RG, Engel J, Read V, Roth GS: Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points.

CAS PubMed Google Scholar Lane MA, Ingram DK, Roth GS: Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk. CAS PubMed Google Scholar Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J: Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.

CAS PubMed PubMed Central Google Scholar Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R: Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. CAS PubMed Google Scholar Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC: Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans.

CAS PubMed Google Scholar Merry BJ: Molecular mechanisms linking calorie restriction and longevity. CAS PubMed Google Scholar Jung KJ, Lee EK, Kim JY, Zou Y, Sung B, Heo HS, Kim MK, Lee J, Kim ND, Yu BP, Chung HY: Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.

CAS PubMed Google Scholar Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR: Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. PubMed Google Scholar Swoap SJ: Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction.

CAS PubMed Google Scholar Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA: Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. CAS PubMed PubMed Central Google Scholar Wang Z, Masternak MM, Al-Regaiey KA, Bartke A: Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

CAS PubMed Google Scholar Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. CAS PubMed PubMed Central Google Scholar Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T, Shima K: Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus?.

CAS PubMed Google Scholar Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME: Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

CAS PubMed Google Scholar Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ: Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria.

CAS PubMed Google Scholar Hyun DH, Emerson SS, Jo DG, Mattson MP, de Cabo R: Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. CAS PubMed PubMed Central Google Scholar Nandy K: Effects of controlled dietary restriction on brain-reactive antibodies in sera of aging mice.

CAS PubMed Google Scholar Weindruch R, Walford RL, Fligiel S, Guthrie D: The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. CAS PubMed Google Scholar Pitsikas N, Carli M, Fidecka S, Algeri S: Effect of life-long hypocaloric diet on age-related changes in motor and cognitive behavior in a rat population.

CAS PubMed Google Scholar Colman RJ, Beasley TM, Allison DB, Weindruch R: Attenuation of sarcopenia by dietary restriction in rhesus monkeys.

PubMed PubMed Central Google Scholar Keenan KP, Ballam GC, Dixit R, Soper KA, Laroque P, Mattson BA, Adams SP, Coleman JB: The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, disease and toxicology.

CAS PubMed Google Scholar Pugh TD, Oberley TD, Weindruch R: Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.

CAS PubMed Google Scholar Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E, CALERIE Pennington Team: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PubMed PubMed Central Google Scholar Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO, the Washington University School of Medicine CALERIE Group: Calorie restriction or exercise: effects on coronary heart disease risk factors.

CAS PubMed Google Scholar Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO: Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. CAS PubMed PubMed Central Google Scholar Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E, Pennington CALERIE Team: Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.

CAS PubMed PubMed Central Google Scholar Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C: Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans.

CAS PubMed PubMed Central Google Scholar Larson-Meyer DE, Newcomer BR, Heilbronn LK, Volaufova J, Smith SR, Alfonso AJ, Lefevre M, Rood JC, Williamson DA, Ravussin E, Pennington CALERIE Team: Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.

CAS Google Scholar Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, Greenway FL, Williamson DA, Smith SR, Ravussin E, Pennington CALERIE team: Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. CAS PubMed Google Scholar Redman LM, Veldhuis JD, Rood J, Smith SR, Williamson D, Ravussin E, for the Pennington CALERIE Team: The effect of caloric restriction interventions on growth hormone secretion in non-obese men and women.

PubMed Google Scholar Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group: Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial.

CAS PubMed PubMed Central Google Scholar Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO, Washington University School of Medicine CALERIE Group: Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss.

PubMed Google Scholar Verdery RB, Walford RL: Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2.

CAS PubMed Google Scholar Walford RL, Mock D, MacCallum T, Laseter JL: Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives.

CAS PubMed Google Scholar Walford RL, Mock D, Verdery R, MacCallum T: Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period.

PubMed Google Scholar Fontana L, Meyer TE, Klein S, Holloszy JO: Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. CAS PubMed PubMed Central Google Scholar Fontana L, Klein S, Holloszy JO, Premachandra BN: Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.

CAS PubMed Google Scholar Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L: Long-term caloric restriction ameliorates the decline in diastolic function in humans.

CAS PubMed Google Scholar Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, Curb JD, Suzuki M: Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.

CAS PubMed Google Scholar Holloszy JO, Fontana L: Caloric restriction in humans. CAS PubMed PubMed Central Google Scholar Crujeiras AB, Parra D, Abete I, Martinez JA: A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects.

CAS PubMed Google Scholar Crujeiras AB, Parra D, Goyenechea E, Abete I, Martinez JA: Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction.

CAS PubMed Google Scholar Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R: The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation.

CAS PubMed Google Scholar Skrha J, Kunesova M, Hilgertova J, Weiserova H, Krizova J, Kotrlikova E: Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients. CAS PubMed Google Scholar Galassetti PR, Nemet D, Pescatello A, Rose-Gottron C, Larson J, Cooper DM: Exercise, caloric restriction, and systemic oxidative stress.

CAS PubMed Google Scholar Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML: Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men.

CAS PubMed Google Scholar Witte AV, Fobker M, Gellner R, Knecht S, Floel A: Caloric restriction improves memory in elderly humans. CAS PubMed PubMed Central Google Scholar Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V: Inhibitory effect of a two day fast on reactive oxygen species ROS generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.

CAS PubMed Google Scholar Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A: Biomarkers of oxidative damage in human disease. CAS PubMed Google Scholar Larson-Meyer DE, Redman L, Heilbronn LK, Martin CK, Ravussin E: Caloric restriction with or without exercise: the fitness versus fatness debate.

PubMed PubMed Central Google Scholar Silverman NE, Nicklas BJ, Ryan AS: Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. CAS PubMed PubMed Central Google Scholar Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP: Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial.

PubMed Google Scholar Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, Hellerstein MK: Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. CAS PubMed Google Scholar Descamps O, Riondel J, Ducros V, Roussel AM: Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting.

CAS PubMed Google Scholar Duan W, Guo Z, Jiang H, Ware M, Mattson MP: Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. CAS PubMed Google Scholar Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M: Cardioprotection by intermittent fasting in rats.

PubMed Google Scholar Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP: Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. CAS PubMed Google Scholar Pedersen CR, Hagemann I, Bock T, Buschard K: Intermittent feeding and fasting reduces diabetes incidence in BB rats.

CAS PubMed Google Scholar Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB: Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p CAS PubMed Google Scholar Wan R, Camandola S, Mattson MP: Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats.

However, these declines were generally no more than expected based on participants' weight loss. Other short-term studies have found that combining physical activity with calorie restriction protects against losses of bone, muscle mass, and aerobic capacity. Some CALERIE participants also experienced brief episodes of anemia diminished number of circulating red blood cells that carry oxygen through the body.

Overall, these findings indicate that while the degree of calorie restriction in CALERIE is safe for normal-weight or moderately obese people, clinical monitoring is recommended. Most research to date has focused on the weight-loss aspect of fasting, primarily in obese people, and only a few small clinical trials have been conducted.

More work is needed to determine which, if any, types of fasting diets have long-term benefits. Observational studies have been conducted in people who practice fasting in one form or another.

In an observational study, the investigator does not determine the treatment to offer and does not randomize subjects into a control group or experimental group. Instead, the investigator records data from real-life situations. For example, one observational study compared people who routinely fasted as part of a religious practice or for another reason to those who did not fast.

It found that those who routinely fasted were less likely to have clogged arteries or coronary artery disease. However, the study did not control for other factors that could have affected the results, such as the kind of diet, quality of food consumed, or use of nutritional supplements.

After decades of research, scientists still don't know why calorie restriction extends lifespan and delays age-related diseases in laboratory animals. Do these results come from consuming fewer calories or eating within a certain timeframe?

Are the results affected by the diet's mix of nutrients? Several studies have focused on what occurs inside the body when caloric intake is restricted. In laboratory animals, calorie restriction affects many processes that have been proposed to regulate the rate of aging.

These include inflammation, sugar metabolism, maintenance of protein structures, the capacity to provide energy for cellular processes, and modifications to DNA. Another process that is affected by calorie restriction is oxidative stress, which is the production of toxic byproducts of oxygen metabolism that can damage cells and tissues.

Several of these processes were similarly affected by calorie restriction in the human CALERIE trial. However, we do not yet know which factors are responsible for calorie restriction's effects on aging or whether other factors contribute. Research supported by NIA has also focused on the effects of intermittent fasting.

During fasting, the body uses up glucose and glycogen, then turns to energy reserves stored in fat. This stored energy is released in the form of chemicals called ketones. These chemicals help cells—especially brain cells—keep working at full capacity.

Some researchers think that because ketones are a more efficient energy source than glucose, they may protect against aging-related decline in the central nervous system that might cause dementia and other disorders. Ketones also may inhibit the development of cancer because malignant cells cannot effectively obtain energy from ketones.

In addition, studies show that ketones may help protect against inflammatory diseases such as arthritis. Ketones also reduce the level of insulin in the blood, which could protect against type 2 diabetes. But too many ketones in the blood can have harmful health effects.

This is one of the reasons researchers want to understand more about how calorie restriction diets work before recommending them. Most calorie-restriction and fasting-diet studies have been in younger people, but researchers are beginning to study older adults.

A clinical trial conducted by NIA is testing the diet in obese people, age 55 to 70, with insulin resistance. This is a condition in which cells do not respond normally to the hormone insulin. This can lead to serious diseases such as diabetes. People in the experimental group can eat at will for 5 days, and then for 2 consecutive days are restricted to to calories per day.

The experiment is designed to find out how 8 weeks of the diet, compared to a regular diet, affects insulin resistance and the brain chemicals that play a role in Alzheimer's disease.

In the coming years, researchers will continue to explore many unresolved questions. What are the long-term benefits and risks of the various eating patterns? Which diets are feasible as a long-term practice? What specific biological effects on aging and disease are triggered by a particular eating pattern?

If a specific way of eating is recommended, at what age is it best to start, and is it safe to continue as you get older? There's insufficient evidence to recommend any type of calorie-restriction or fasting diet.

A lot more needs to be learned about their effectiveness and safety, especially in older adults. You may be tempted to try one of these eating patterns. It's important to make sure that whatever you try provides you with a safe level of nutrition.

Talk with your healthcare provider about the benefits and risks before making any significant changes to your eating pattern. An official website of the National Institutes of Health. Share: Print page Facebook share Linkedin share X social media share. Research Highlights Calorie restriction and fasting diets: What do we know?

August 14, On this page: What Are the Different Forms of Calorie Restriction and Fasting? What's the Evidence from Animal Studies? What's the Evidence from Human Studies of Calorie Restriction? What's the Evidence from Human Studies of Fasting? How Does Calorie Restriction or Fasting Work?

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Nutrition Set meal frequency volume 10Article number: Cite Set meal frequency intame. Metrics details. Considerable interest has been shown in the redtrictions of caloric restriction CR Vietary improve multiple parameters Enhance cognitive capacity health and to extend lifespan. Several alternatives to CR exist. CR combined with exercise CE consists of both decreased caloric intake and increased caloric expenditure. Alternate-day fasting ADF consists of two interchanging days; one day, subjects may consume food ad libitum sometimes equaling twice the normal intake ; on the other day, food is reduced or withheld altogether.

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Counting Calories Is A Ridiculous Way To Try And Lose Weight - Think - NBC News Caloric intake and dietary restrictions

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