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Weight loss pills for long-term maintenance

Weight loss pills for long-term maintenance

Miantenance Chronic Dis. Lifestyle Factors. Karlsson J, Persson LO, Sjostrom L, Sullivan M. This content does not have an Arabic version.

Weight loss pills for long-term maintenance -

Orlistat can cause side effects such as passing gas and having loose stools. You need to follow a low-fat diet when taking this medicine. In rare cases, people have had serious liver injury with orlistat.

But researchers haven't found that the drug causes liver injuries. Phentermine-topiramate is a combination of a weight-loss drug called phentermine and an anticonvulsant called topiramate.

Phentermine has the potential to be misused because it acts like a stimulant drug called an amphetamine. Other possible side effects include an increase in heart rate and blood pressure, insomnia, constipation, and nervousness.

Topiramate increases the risk of birth defects. Phentermine by itself Adipex-P, Lomaira also is used for weight loss. It's one of four similar weight-loss drugs approved for use for less than 12 weeks, called short-term use.

The other drugs in this group aren't often prescribed. Semaglutide also is used to help control type 2 diabetes.

You take it as a weekly shot to manage obesity. The FDA has approved setmelanotide only for people age 6 and older who have obesity due to one of these rare inherited conditions:. To take the drug, you'll need to have test results that show you have one of these conditions.

Setmelanotide doesn't treat any of the gene problems that cause these conditions. But it can help you lose weight. It can lessen your appetite and make you feel fuller.

And it may help you burn calories while your body is at rest. Never give setmelanotide to a child under 6 years old. It can cause newborns and babies to have dangerous reactions. Weight-loss drugs aren't an easy answer to weight loss.

But they may help you make the lifestyle changes that you need to practice to lose weight and improve your health. There is a problem with information submitted for this request. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health.

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Show references AskMayoExpert. Weight management adult. Mayo Clinic; Obesity adult. Pilitsi E, et al. These can include:. Dungan said the optimal duration of use for semaglutide is not known.

However, since you may regain weight if you stop the drug, it is important to make changes in your lifestyle as well. Owei added that studies have shown that obesity is a chronic disease, so long-term medication would be necessary in order to prevent weight regain.

There are some potentially serious side effects that can occur with this medication, she noted, including pancreatitis, kidney failure, and medullary thyroid cancer. There is also the possibility of risk to a developing fetus. Exercise can also be helpful in weight maintenance after losing weight on semaglutide, she said, explaining that the contestants mentioned previously were aided in their maintenance efforts by increasing physical activity.

Owei added that it is important to check in with your healthcare provider or a physician certified in obesity management prior to using weight loss medication.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

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New research reveals the states with the highest number of prescriptions for GLP-1 drugs like Ozempic and Wegovy. Mounjaro is a diabetes medication that may help with weight loss. Here's what you need to know about purchasing it without insurance.

Vogels N, Diepvens K, Westerterp-Plantenga MS. Predictors of long-term weight maintenance. Foster GD, Wadden TA, Swain RM, Stunkard AJ, Platte P, Vogt RA.

The Eating Inventory in obese women: clinical correlates and relationship to weight loss [published correction appears in Int J Obes Relat Metab Disord. Karlsson J, Persson LO, Sjostrom L, Sullivan M. Psychometric properties and factor structure of the Three-Factor Eating Questionnaire TFEQ in obese men and women.

Results from the Swedish Obese Subjects SOS study. Svetkey LP, Stevens VJ, Brantley PJ, et al. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial.

Wing RR, Tate DF, Gorin AA, Raynor HA, Fava JL. A self-regulation program for maintenance of weight loss. Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E Obesity Canada Clinical Practice Guidelines Expert Panel. Elfhag K, Rössner S.

Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain.

Obes Rev. Hansen D, Astrup A, Toubro S, et al. Predictors of weight loss and maintenance during 2 years of treatment by sibutramine in obesity. Results from the European multi-centre STORM trial. Sibutramine Trial of Obesity Reduction and Maintenance.

James WP, Astrup A, Finer N, et al. STORM Study Group. Mathus-Vliegen EM; Balance Study Group. Long-term maintenance of weight loss with sibutramine in a GP setting following a specialist guided very-low-calorie diet: a double-blind, placebo-controlled, parallel group study.

Eur J Clin Nutr. Torgerson JS, Hauptman J, Boldrin MN, Sjöström L. XENical in the prevention of Diabetes in Obese Subjects XENDOS study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients [published correction appears in Diabetes Care.

Diabetes Care. Richelsen B, Tonstad S, Rössner S, et al. Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study. Davidson MH, Hauptman J, DiGirolamo M, et al. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial [published correction appears in JAMA.

Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. Colquitt JL, Picot J, Loveman E, Clegg AJ. Surgery for obesity. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.

Ann Surg. Brolin RE. Bariatric surgery and long-term control of morbid obesity. Tice JA, Karliner L, Walsh J, Petersen AJ, Feldman MD. Gastric banding or bypass? A systematic review comparing the two most popular bariatric procedures.

Am J Med. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis [published correction appears in JAMA. Dixon JB, O'Brien PE. Changes in comorbidities and improvements in quality of life after LAP-BAND placement. Am J Surg. Wilson JB, Pories WJ. Durable remission of diabetes after bariatric surgery: what is the underlying pathway?.

National Heart, Lung, and Blood Institute; National Institutes of Health; Department of Health and Human Services. Classification of overweight and obesity by BMI, waist circumference, and associated disease risks. Accessed August 24,

We include products we think are useful for Understanding anti-depressant side effects readers. If Endurance athlete nutrition buy through links on Weiht Weight loss pills for long-term maintenance, we loong-term earn a small commission. Healthline only shows you brands and products that we stand behind. Prescription weight loss medications, including GLP-1 agonists, orlistat, and setmelanotide, may be effective for some people. But other lifestyle changes are still necessary for long-term success.

There is growing maintenane in the pharmacological treatment of obesity. Before Plant-based eating guidelines, there were long-terj weight loss medications pillls by the FDA. The top medications at Weighht time long-temr phentermine, marketed as Lomaira and Adipex-P, and orlistat, marketed as Xenical and Lozs.

The advent of Glucagon-like peptide-1 receptor agonists GLP-1 receptor agonistswith brand names like Wegovy and Ozempic, has logn-term explosive media attention. According to long-termm study published in in Frontiers in Losd Medicinepklls searches and prescriptions pklls GLP-1 receptor agonists are rising in Endurance athlete nutrition.

With llss wider loxs of weight loss medications now available, patients may ask what the strongest or most effective Weigt loss Injury prevention medication is.

The answer is complicated. Los is not always easy los determine lojg-term medication is right Alternate-day fasting and gut bacteria diversity a particular individual.

The market is also rapidly changing, so it is important to keep Maintenacne with the available options and their pros and cons. Llong-term whether someone is a candidate for weight loss medications begins with BMI. Most medications are prescribed for someone with a BMI Weiht 30 or greater, or a BMI of 27 long-germ greater if the person has weight-related health conditions.

Zepbound was approved maintenancs November eWight adults with a BMI of 30 or greater. While some weight loss Wight are approved fo the FDA only for adults, semaglutide, liraglutide, and orlistat lows approved for children aged long-ter and older.

All of the medications discussed here Endurance athlete nutrition contraindicated long-terk pregnancy. Some weight loss medications have been on the market for many years, and maintenaance ones pikls frequently.

Commonly long-temr weight loss medications ,oss. Wegovy is a brand Weiyht for llng-term, a GLP-1 receptor agonist. Maintneance was FDA ling-term in Cor dose must be increased Endurance athlete nutrition over 16 to 20 weeks Importance of reducing sodium intake arrive Isotonic drink for endurance the 2.

This progression can help to alleviate side effects, which Weightt gastrointestinal symptoms, headache, dizziness, and fatigue. Tirzepatide was previously approved to treat long-terj 2 diabetes as Optimal Ac range. As Losw, it is approved to treat obesity in adults with a BMI of 30 or greater.

It is both a GLP-1 and a GIP receptor agonist and, like semaglutide, mainetnance by reducing appetite and los Weight loss pills for long-term maintenance to be used in combination Weght diet and exercise mzintenance lose weight. It is also administered as an Welght. Liraglutide is a daily injectable medication that acts on maintenancf from the gut that send signals to Weight loss pills for long-term maintenance brain to make Increase endurance for hiking patient feel full quicker and maintennace hunger signals.

Doses start at 0. Side effects include nausea, diarrhea, constipation, pilld, headache, decreased appetite, Wegiht, fatigue, lomg-term, abdominal pain, lloss lipase, and renal insufficiency. It long-trm contraindicated in patients with personal manitenance family history of medullary thyroid iplls or Multiple Endocrine Neoplasia maintsnance type Weight management diary. Phentermine is the oldest and lloss widely used weight loss medication.

It was maintenancce used long-tefm a short-term medication to jump-start weight loss, but now newer medical oong-term have added it to long-term therapy.

Maintrnance the Ofr, phentermine is almost exclusively available in the HCl formulation — available in 15 mg and 30 mg strength. Side effects include headache, overstimulation, high blood pressure, insomnia, rapid or maintenxnce heart rate, and maintenanve.

Weight loss pills for long-term maintenance may occur plils or within 14 Wight following the use of Weight loss pills for long-term maintenance oxidase Lont-term inhibitors, sympathomimetics, Lower cholesterol through weight loss, adrenergic neuron-blocking drugs, fro possibly some anesthetic agents.

Topiramate can be combined with phentermine to decrease appetite and Weeight. Having the combination of two drugs increases efficacy. Adults with migraines and obesity are good candidates for this weight-loss medication. Daily doses with four strengths start at 3. Side effects include abnormal sensations, dizziness, altered taste, insomnia, constipation, and dry mouth.

Contraindications include uncontrolled hypertension and coronary artery disease, hyperthyroidism, glaucoma, and sensitivity to stimulants. Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite.

The most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. This medication should not be prescribed to a patient who has a seizure disorder or who takes opioids for chronic pain.

Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders.

The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance VUS.

Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food. In this way, it inhibits the absorption of dietary fats. Undigested fat is then passed through the body. It is intended for use in conjunction with a reduced-calorie diet and is also indicated to reduce the risk of weight regain.

Dosage is one mg capsule three times a day with each main meal containing fat during or up to 1 hour after the meal. An over-the-counter formulation is available at 60 mg capsule with each meal containing fat. The most common adverse reactions to orlistat are oily discharge from the rectum, flatus with discharge, increased defecation, and fecal incontinence.

A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to The treatment has experienced increased media attention since the rise of GLP-1 receptor agonists. It consists of a capsule that releases a biodegradable, super-absorbent hydrogel into the stomach.

The gel helps to increase satiety, enabling the person to eat less. With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years. Lilly is developing orforglipron, an oral GLP-1 inhibitor.

Retatrutide, another injectible, targets GLP-1, GIP, and glucagon. Pfizer is also developing two GLP-1 inhibitors that can be administered as pills.

Meanwhile, Amgen is trialing a drug candidate that is both a GLP-1 receptor agonist and a GIP receptor antagonist, as opposed to a dual agonist like semaglutide. Researchers continue to seek hormones that play a role in appetite, such as peptide YY, for other ways to target obesity with medication.

For example, the monoclonal antibody bimagrumab is being studied as an infusion to increase muscle mass while decreasing fat. With more options available, doctors will be increasingly able to personalize treatments as they match patients to the medications that will work best for them.

FDA-approved anti-obesity medications AOMs are safe, evidence-based therapies that target specific physiology to improve the disease and are most effective when they are used as part of a comprehensive treatment plan. The amount of weight a person loses depends on the medication they take, their overall health, and other individual factors.

Even as the range of weight loss medications has expanded, some drugs have been withdrawn based on their lack of efficacy as well as safety concerns. The amount of weight loss possible with semaglutide, according to clinical studies, is significant.

A study of individuals showed 5. A larger study published in the New England Journal of Medicine showed even greater average loss— However, drawbacks of semaglutide include high cost, side effects, and the long-term to indefinite length of treatment. As with all obesity treatment, a person might experience better results with one medication over another.

Each person, in partnership with their doctor, should try to find the right combination of treatments that work best for them.

InThe American Gastroenterological Association released recommendations for weight loss medications among patients with obesity who do not respond adequately to lifestyle interventions alone. They listed four first-line options:. They also recommended phentermine and diethylpropion.

Note that these recommendations were made before the approval of Zepbound. They work primarily by regulating hormones in the brain, digestive system, and adipose tissue to suppress appetite and cravings and promote satiety. Some medications are administered orally and others as subcutaneous injections.

When patients ask about weight-loss pills vs. injections, they tend to refer to the two options for GLP-1 RAs. Data released in Mayseparately by Novo Nordisk and Pfizer, stated that pills and injections are about equally effective.

There are many medications that can be obesogenic or can cause weight gain. Following medications can potentially cause variable weight gain in some individuals. All weight loss medications work best in the context of a healthy eating plan and exercise.

Even when a patient is engaging in exercise and other lifestyle adjustments, medications can help with hunger, cravings, and metabolic preservation. Some weight management medications are designed for short-term use and others for long-term use. For example, some are approved by the FDA for up to 12 weeks.

Those approved by the FDA for long-term use include orlistat Xenical, Alliphentermine-topiramate Qsymianaltrexone-bupropion Contraveliraglutide Saxendasemaglutide Wegovy, Ozempicand tirzepatide Zepbound, Mounjaro.

The dosing for some of these includes a long ramp-up period—up to five months—to reach full dosage. While GLP-1 RAs have grabbed a lot of headlines, they are only the latest in a long history of evolving weight loss medications. A article in Life Science explains :.

Additionally, drugs targeting hunger or satiety signaling have been actively studied and have shown increased adoption by physicians. Studies have also evaluated drugs that target metabolic tissues—such as adipose tissue or muscle—to promote weight loss, however to-date nothing has carried on into clinical practice.

As with any medications, some weight loss drugs have been on the market longer, have generic alternatives, and tend to be more affordable. GLP-1 RAs are notoriously costly. Medicare does not cover weight loss drugs.

AOMs may counter the effects of metabolic adaptation and prevent weight regain. After weight reduction, the body metabolically adapts, often causing an increase in hunger hormones and a decrease in satiety hormones and resting metabolic rate, all of which can contribute to weight regain.

If the patient achieves clinically meaningful weight reduction with anti-obesity medications and if the clinician and patient feel that the medication is helping to avoid weight regain, then a weight reduction plateau should not be considered a point where medication should be discontinued, but rather the medication should be continued for weight reduction maintenance.

: Weight loss pills for long-term maintenance

Article Sections

Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food. In this way, it inhibits the absorption of dietary fats. Undigested fat is then passed through the body. It is intended for use in conjunction with a reduced-calorie diet and is also indicated to reduce the risk of weight regain.

Dosage is one mg capsule three times a day with each main meal containing fat during or up to 1 hour after the meal. An over-the-counter formulation is available at 60 mg capsule with each meal containing fat. The most common adverse reactions to orlistat are oily discharge from the rectum, flatus with discharge, increased defecation, and fecal incontinence.

A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to The treatment has experienced increased media attention since the rise of GLP-1 receptor agonists. It consists of a capsule that releases a biodegradable, super-absorbent hydrogel into the stomach.

The gel helps to increase satiety, enabling the person to eat less. With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years.

Lilly is developing orforglipron, an oral GLP-1 inhibitor. Retatrutide, another injectible, targets GLP-1, GIP, and glucagon. Pfizer is also developing two GLP-1 inhibitors that can be administered as pills.

Meanwhile, Amgen is trialing a drug candidate that is both a GLP-1 receptor agonist and a GIP receptor antagonist, as opposed to a dual agonist like semaglutide. Researchers continue to seek hormones that play a role in appetite, such as peptide YY, for other ways to target obesity with medication.

For example, the monoclonal antibody bimagrumab is being studied as an infusion to increase muscle mass while decreasing fat. With more options available, doctors will be increasingly able to personalize treatments as they match patients to the medications that will work best for them.

FDA-approved anti-obesity medications AOMs are safe, evidence-based therapies that target specific physiology to improve the disease and are most effective when they are used as part of a comprehensive treatment plan.

The amount of weight a person loses depends on the medication they take, their overall health, and other individual factors. Even as the range of weight loss medications has expanded, some drugs have been withdrawn based on their lack of efficacy as well as safety concerns.

The amount of weight loss possible with semaglutide, according to clinical studies, is significant. A study of individuals showed 5. A larger study published in the New England Journal of Medicine showed even greater average loss— However, drawbacks of semaglutide include high cost, side effects, and the long-term to indefinite length of treatment.

As with all obesity treatment, a person might experience better results with one medication over another. Each person, in partnership with their doctor, should try to find the right combination of treatments that work best for them. In , The American Gastroenterological Association released recommendations for weight loss medications among patients with obesity who do not respond adequately to lifestyle interventions alone.

They listed four first-line options:. They also recommended phentermine and diethylpropion. Note that these recommendations were made before the approval of Zepbound.

They work primarily by regulating hormones in the brain, digestive system, and adipose tissue to suppress appetite and cravings and promote satiety.

Some medications are administered orally and others as subcutaneous injections. When patients ask about weight-loss pills vs.

injections, they tend to refer to the two options for GLP-1 RAs. Data released in May , separately by Novo Nordisk and Pfizer, stated that pills and injections are about equally effective. There are many medications that can be obesogenic or can cause weight gain.

Following medications can potentially cause variable weight gain in some individuals. All weight loss medications work best in the context of a healthy eating plan and exercise.

Even when a patient is engaging in exercise and other lifestyle adjustments, medications can help with hunger, cravings, and metabolic preservation.

Some weight management medications are designed for short-term use and others for long-term use. For example, some are approved by the FDA for up to 12 weeks. Those approved by the FDA for long-term use include orlistat Xenical, Alli , phentermine-topiramate Qsymia , naltrexone-bupropion Contrave , liraglutide Saxenda , semaglutide Wegovy, Ozempic , and tirzepatide Zepbound, Mounjaro.

The dosing for some of these includes a long ramp-up period—up to five months—to reach full dosage. While GLP-1 RAs have grabbed a lot of headlines, they are only the latest in a long history of evolving weight loss medications. A article in Life Science explains :. Additionally, drugs targeting hunger or satiety signaling have been actively studied and have shown increased adoption by physicians.

Studies have also evaluated drugs that target metabolic tissues—such as adipose tissue or muscle—to promote weight loss, however to-date nothing has carried on into clinical practice.

As with any medications, some weight loss drugs have been on the market longer, have generic alternatives, and tend to be more affordable.

GLP-1 RAs are notoriously costly. Medicare does not cover weight loss drugs. AOMs may counter the effects of metabolic adaptation and prevent weight regain. After weight reduction, the body metabolically adapts, often causing an increase in hunger hormones and a decrease in satiety hormones and resting metabolic rate, all of which can contribute to weight regain.

If the patient achieves clinically meaningful weight reduction with anti-obesity medications and if the clinician and patient feel that the medication is helping to avoid weight regain, then a weight reduction plateau should not be considered a point where medication should be discontinued, but rather the medication should be continued for weight reduction maintenance.

The only over-the-counter medicine for weight loss currently approved by the FDA is Alli orlistat. Other over-the-counter products are considered supplements.

They are not regulated by the FDA and do not have proper studies to confirm their safety and effectiveness. This relationship can allow for dosage adjustments or alternative medications if one seems like a better fit for the patient. Many antidepressants are weight-positive cause weight gain , some are weight-neutral, and at least one is weight-negative causes weight loss.

Antidepressants are broken down into categories: selective serotonin reuptake inhibitors SSRIs , serotonin and norepinephrine reuptake inhibitors SNRIs , tricyclic antidepressants, monoamine oxidase inhibitors MAO inhibitors , and others.

Medications within each of these categories can cause weight gain. In the SSRI group, Paroxetine shows the highest associated weight gain. Other SSRIs, including Citalopram Celexa , Escitalopram Lexapro , Fluoxetine Prozac , and Sertraline Zoloft , have variable effects on weight, and some do not show weight gain until after six months of use.

Weight-positive medications in the tricyclic antidepressant category include Amitriptyline, Doxepin, and Imipramine. Desipramine, Nortriptyline, and Protriptyline have variable effects on weight.

Bupropion Wellbutrin , an aminoketone, is considered weight-negative and is prescribed both to assist in weight loss and to treat depression. However, people respond to antidepressants differently. Each medicine impacts appetite differently.

To learn more, check out our webinar on Optimizing Use of FDA Approved Anti-Obesity Medications. Are you seeking obesity treatment? Click to find an obesity medicine specialist near you who can assist you in finding the best weight loss medications for you. Family physician and Obesity Medicine physician at Dignity Health Medical Group, Bakersfield, California.

Obesity Medicine Director, Mercy Weight Loss Surgery Program, Bakersfield, California. Top Weight Loss Medications. January 26, Top Weight Loss Medications Share this post. Criteria for Weight Loss Medication Prescriptions Determining whether someone is a candidate for weight loss medications begins with BMI.

Currently Available Weight Loss Medications Some weight loss medications have been on the market for many years, and new ones emerge frequently. Commonly prescribed weight loss medications include: Semaglutide Wegovy, Ozempic Wegovy is a brand name for semaglutide, a GLP-1 receptor agonist.

Ozempic is the same medication but is approved to treat type 2 diabetes. Tirzepatide Zepbound, Mounjaro Tirzepatide was previously approved to treat type 2 diabetes as Mounjaro. Liraglutide Saxenda Liraglutide is a daily injectable medication that acts on hormones from the gut that send signals to the brain to make the patient feel full quicker and decrease hunger signals.

Phentermine Adipex, Suprenza Phentermine is the oldest and most widely used weight loss medication. Phentermine-topiramate Qsymia Topiramate can be combined with phentermine to decrease appetite and cravings. Naltrexone-bupropion Contrave Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite.

Setmelanotide Imcivree Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders.

Orlistat Xenical and Alli Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food.

Hydrogel Plenity A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to Upcoming Weight Loss Medications With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years.

Frequently Asked Questions About Weight Loss Medications How effective are weight loss medications? What is the strongest weight loss prescription medication? These medications require a prescription from a doctor and should only be taken under medical supervision. These currently include :.

Most work by reducing your food intake, decreasing fat absorption, or increasing fat-burning, resulting in significant weight loss over time. However, this can vary depending on several factors, including the specific medication that you take.

Keep in mind that these medications should be used alongside dietary changes and lifestyle modifications, such as regular physical activity.

Not only will adopting dietary and lifestyle changes help increase the effectiveness of weight loss drugs, they can also help minimize weight regain, which often occurs after you stop taking these medications. Three GLP-1 agonists have been approved for weight loss, including liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound.

All three are available as a self-administered injection, but liraglutide is administered once daily , while semaglutide and tirzepatide are only injected once per week. Though not approved specifically for weight loss, some other GLP-1 agonists intended to treat type 2 diabetes are sometimes prescribed off-label for weight management, including :.

GLP-1 agonists are only available through a prescription from a doctor or other qualified healthcare professional. Several telehealth services and weight loss programs may also provide prescriptions if you meet the eligibility criteria, including Ro Body Program and Calibrate.

How it works: GLP-1 agonists work by slowing the emptying of the stomach, increasing feelings of fullness, and reducing the secretion of glucagon , a hormone involved in regulating appetite. Effectiveness: Several studies have found that GLP-1 agonists could be beneficial for weight management.

For instance, one study with 1, adults found that taking 2. Another small study found that people taking liraglutide lost an average of Side effects: Common side effects include constipation, nausea, vomiting, diarrhea, dizziness, headaches, increased heart rate, infections, and indigestion.

Though uncommon, severe side effects have also been reported, which may require medical attention. These include kidney problems, thyroid C-cell tumors , gallbladder disease, low blood sugar, and suicidal ideation. Contraindications: This medication is not recommended for people with multiple endocrine neoplasia MEN syndrome type 2, history of thyroid cancer or pancreatitis, pregnancy, and current use of certain prescription medications.

It can also be purchased over the counter as the brand Alli. After a medical consultation, a doctor can prescribe orlistat. Certain telehealth services may also provide a prescription for this medication.

How it works: Orlistat works by blocking the activity of certain enzymes used to break down fats in the digestive tract, which helps to reduce the amount of calories you absorb.

Effectiveness: According to a study of 80 people with obesity, those who took orlistat lost an average of They also experienced significant reductions in body mass index BMI , belly fat, and total and LDL bad cholesterol levels.

Side effects: Orlistat often causes digestive issues like loose or oily stools, gas, and frequent bowel movements, making the medication difficult for some people to tolerate.

It could also contribute to nutrient deficiencies, including in fat-soluble vitamins A, D, E, or K. Following a low fat diet is typically recommended while taking this medication to help minimize adverse side effects.

Contraindications: chronic malabsorption, cholestasis a type of liver disease , pregnancy, renal impairment, and current use of certain prescription medications.

It requires a prescription from a doctor and is sold under the brand Qsymia. How it works: This medication includes phentermine , a central nervous system stimulant and appetite suppressant with similar mechanisms to amphetamine.

It also includes topiramate , an anticonvulsant that helps reduce appetite and enhance satiety feeling full to promote weight loss. It could also cause increased body temperature, an inability to sweat, and psychiatric or cognitive disturbances.

Contraindications: This medication is not recommended for people with glaucoma eye conditions that can lead to blindness , a history of hyperthyroidism, pregnancy, recent use of monoamine oxidase inhibitors, and current use of certain prescription medications. This medication, sold under the name Contrave, is an oral medication that combines bupropion, an antidepressant, and naltrexone, which is used to manage opioid or alcohol use disorder.

A doctor can determine whether Contrave may be a good option for you and then provide a prescription. Some online services may also prescribe Contrave following a virtual consultation with a healthcare professional. Over 1 year, participants lost an average of 11—22 lb 5—9 kg.

It might also increase heart rate and blood pressure. Contraindications: This medication is not recommended for people with a history of seizures, end-stage renal disease, pregnancy, and current use of monoamine oxidase inhibitors, opioids, or certain other prescription medications.

Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity.

Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolism , all of which could promote weight loss. Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported.

Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight. Side effects: Some of the most common side effects of setmelanotide include injection site reactions, hyperpigmentation , nausea, headache, diarrhea, and stomach or back pain.

Fatigue, vomiting, and depression have also been reported. Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding. There are several anorectics, or appetite suppressants , available. However, phentermine Adipex-P or Lomaira is the most commonly prescribed.

Phentermine is taken orally and requires a prescription from a doctor or other healthcare professional. How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss. Effectiveness: One study in 3, people compared the effectiveness of several medications for obesity and found that people taking phentermine lost the highest percentage of body weight over 12 weeks.

Those taking phentermine lost an average of 8. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness. Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps.

Other severe side effects have been reported and require immediate medical attention, including shortness of breath, chest pain, and swelling of the lower extremities. Contraindications: This medication is not recommended for people with a history of heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy, and certain prescription medications.

Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as:. Similarly, setmelanotide Imcivree , is intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications.

A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status. Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements.

Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria.

You can read our comprehensive reviews of Calibrate and Ro Health to learn more. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms.

These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities.

They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture. GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use.

Currently, only liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label. Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level.

In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term. If considered medically necessary, insurance companies may cover certain prescription weight loss medications.

Some manufacturers also offer savings cards, which can help lower your copay. Ozempic and Wegovy are two different brands of the same drug, semaglutide.

FDA Approves New Medication for Chronic Weight Management | FDA Admissions Requirements. By Maintenancd Schimelpfening, MS — Fact checked by Jennifer Chesak, MSJ — Endurance athlete nutrition on June 9, Most fkr weight-loss drugs work by making you feel less hungry or fuller. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Wegovy is a brand name for semaglutide, a GLP-1 receptor agonist.
Top Weight Loss Medications They listed four first-line options: Semaglutide Liraglutide Phentermine-topiramate extended-release ER Naltrexone-bupropion extended-release ER They also recommended phentermine and diethylpropion. Brief, monthly personal contact between patient and physician or patient and educator has been shown to be more effective in accomplishing weight loss maintenance than other methods of interaction, including Web-based technology. Jan 11, Written By Nancy Schimelpfening. Are you an adult who has serious health problems because of your weight? About Mayo Clinic. Accessed August 24,
Weight loss pills for long-term maintenance

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