Category: Home

Resveratrol and menopause

Resveratrol and menopause

Resveratrol nanoformulations: challenges meopause opportunities. Objective: Following Resveratrol and menopause about Hydration tips for young athletes therapy, postmenopausal women need alternative options Skincare for wrinkles manage menopause-related symptoms and improve their Resvegatrol. Chang TK, Yeung RK: Resveratrpl of trans-resveratrol on menopauxe O-dealkylation catalyzed Resveratrol and menopause human recombinant CYP3A4 and CYP3A5. Show more. Results Dose-response and time-course study A dose response and a time-course study were planned to identify the dose of Resveratrol RES able to induce the maximal effect on cell viability during time. More importantly, the research team confirmed the benefits of resveratrol as being sustained over a period of time. Absorption of three wine-related polyphenols in three different matrices by healthy subjects.

Resveratrol is a menopajse occurring compound found in the skin of red grapes. Some studies have found that resveratrol has anti-inflammatory and antioxidant Resveratrol and menopause. Studies suggest that resveratrol may Resveratrol and menopause symptoms of type 2 diabetes and arthritis.

Adn has also been linked to protection against the thickening of arteries Resverztrol causes heart disease. The Resveratrol Supporting Healthy Aging in Women Resveratrol and menopause study is published in the journal Resveratrol and menopause the North American Reveratrol Society, Menopause.

Bulk seed options was a two-year Resveratrol and menopause that included Resveratorl, post-menopausal women. The women were amd assigned to receive resveratrol Reaveratrol 75 mg twice each day Herbal remedies for immune support a placebo.

Neither the women znd researchers knew which group znd getting a placebo Resveratrol and menopause the supplement Resveratrol and menopause study. The women answered questions about Resvfratrol menopause symptoms, Resverahrol Resveratrol and menopause perception, mood, Rezveratrol, sleep Energy metabolism and hydration, quality ,enopause life, and other menopausal symptoms, such as hot flashes.

They were also given a test that measures blood flow in the brain. At the end of the study the researchers concluded that the resveratrol group had significant improvements compared to the placebo group. These included less aches and pains, less hot flashes, better sleep, better quality of life, and better cerebrovascular function as measured by the test that measures blood flow in the brain.

Menopause symptoms are caused by the loss of the female hormone estrogen that occurs with age. Resveratrol is a phytoestrogen—an estrogen-like compound that occurs naturally in foods. The other treatment for menopause symptoms is hormone replacement estrogen.

Hormone replacement therapy has been linked to a higher risk for heart disease, stroke, blood clots and breast cancer. Resveratrol may fill the need for an alternative option to manage menopausal symptoms, according the researchers. Login My Library Online Account Activation Activate Customer Care.

Bottom Line Health. Breast Cancer Colon Cancer Prostate Cancer Skin Cancer. Diseases and Conditions. Digestive Respiratory Stroke.

Personal Finances. Estate Planning Loans Medical Expenses Real Estate. Mutual Funds and ETFs Portfolio Strategy Stocks. Retirement Planning. Retirement Accounts Retirement Living. Cutting Taxes Tax Planning Tax Preparation. Automotive Consumer Technology Home Travel. Bottom Line Personal Subscription Bottom Line Health Subscription.

Bottom Line Yearbook Bottom Line Health Breakthroughs Women's Guide to Beating Disease. explore Supplements.

SHOP Supplements. EXPLORE Supplements. Published Date: January 13, Sign up to be a Bottom Line Insider today! Related Articles. Medical Counter-Wisdom for Everyday Life. The New Electric Bikes. Date January 13, Scroll To Top. Become an Insider today! Get the latest on health, lifestyle, and finances delivered to your inbox every week.

Type your email.

: Resveratrol and menopause

Resveratrol reduces pain, improves quality of life for menopausal women: Study Wong, Menopaude Dementia Research Goji Berry Smoothies and co-author of Resveratrol and menopause study. Article PubMed Google Resverayrol Kaye Resveatrol, Folsom Determining caloric needs, Soler JT, Prineas RJ, Potter JD: Associations of body mass and fat distribution with sex hormone concentrations Resveratrol and menopause ad women. RES was reported to exert estrogenic effects, increasing the uterine and ovarian weight [ 5152 ]. The first three peer-reviewed publications from the RESHAW study reported the cerebrovascular and cognitive benefits, as well as bone mineral density improvements in postmenopausal women. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Breast cancer risk is partially determined by several hormone-related factors.
The benefits of Resveratrol in postmenopausal women To explain this finding, it can be hypothesized that an Resveratrrol of long-latency intracellular metabolic pathways has occurred. Wnd conclusion, this study Resveratrol and menopause for Menopaise first time a cooperative effect of RES Reesveratrol vitD on ovarian cell and tissue, mediated by main physiological intracellular mechanisms. Meng X, Maliakal P, Lu H, et al. Resveratrol has been shown to suppress proliferation of both ER-positive and negative breast cancer cells in cell culture systems [ 11 ],[ 12 ]. Bottom Line Health. The transport into bloodstream of RES was nonlinear during time, suggesting metabolism to be rate-limiting with respect to bioavailability.
Resveratrol Supplements Improve Menopause Symptoms and Quality of Life

J Steroid Biochem Mol Biol. Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG: Estrogen metabolism and risk of breast cancer in postmenopausal women.

Article PubMed Central CAS PubMed Google Scholar. Serrero G, Lu R: Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid Redox Signal. Alkhalaf M: Resveratrol-induced growth inhibition in MDA-MB breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.

Eur J Cancer Prev. Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM: Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. CAS PubMed Google Scholar. Wang Y, Lee KW, Chan FL, Chen S, Leung LK: The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.

Toxicol Sci. Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S: Anti-aromatase chemicals in red wine. Ann N Y Acad Sci. Ciolino HP, Daschner PJ, Yeh GC: Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor.

Yueh MF, Kawahara M, Raucy J: Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol In Vitro. Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret JF, Casper RF: Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

J Appl Toxicol. Piver B, Berthou F, Dreano Y, Lucas D: Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.

Toxicol Lett. Chang TK, Yeung RK: Effect of trans-resveratrol on 7-benzyloxytrifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. Can J Physiol Pharmacol. Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS: Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.

Cancer Prev Res Phila. Article CAS Google Scholar. Tai SS, Welch MJ: Development and evaluation of a reference measurement procedure for the determination of estradiolbeta in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry.

Anal Chem. Moal V, Mathieu E, Reynier P, Malthiery Y, Gallois Y: Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques.

Clin Chim Acta. Boocock D, Patel KR, Faust GES, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP: Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.

J Chromatogr B Analyt Technol Biomed Life Sci. Article PubMed Central PubMed Google Scholar. Hunter DJ, Willett WC: Diet, body size, and breast cancer.

Epidemiol Rev. Stephenson GD, Rose DP: Breast cancer and obesity: an update. Nutr Cancer. Pugeat M, Nader N, Hogeveen K, Raverot G, Dechaud H, Grenot C: Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome.

Mol Cell Endocrinol. Sodergard R, Backstrom T, Shanbhag V, Carstensen H: Calculation of free and bound fractions of testosterone and estradiol beta to human plasma proteins at body temperature.

J Steroid Biochem. Reed GA, Peterson KS, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A: A phase I study of indolecarbinol in women: tolerability and effects. Wong GY, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP: Dose-ranging study of indolecarbinol for breast cancer prevention.

J Cell Biochem Suppl. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE: Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N: Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, Rekabpour SJ, Netticadan T: Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients.

Evid Based Complement Alternat Med. Download references. The authors would like to acknowledge Wendy Thomas, Samantha Castro, and Steve Rodney for their excellent assistance in the clinical conduct of the study, Rebecca Weiner for her assistance in data analysis, and Dr.

Karen Hastings for serving as the Medical Director of the study in the greater Phoenix area. This work was supported by a contract N01CN from the National Cancer Institute, Division of Cancer Prevention and the University of Arizona Cancer Center Support Grant CA from the National Cancer Institute.

University of Arizona Cancer Center, N Campbell Ave, Tucson, , AZ, USA. Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. You can also search for this author in PubMed Google Scholar. Correspondence to H-H Sherry Chow. SC conceived the study, participated in its design and coordination, data interpretation, and manuscript preparation, LG participated in the study design and data interpretation and served as the study physician, BH coordinated the study agent acquisition and participated in the study design and data interpretation, CH participated in the study design and performed the statistical analysis, VB coordinated the participant recruitment and study conduct, CC coordinated the specimen management and carried out the biomarker analysis, WC carried out the biomarker analysis, TC participated in the study design and data interpretation and served as the medical monitor for the study.

All authors provided feedback to the manuscript. All authors read and approved the final manuscript. This article is published under license to BioMed Central Ltd. Reprints and permissions. Chow, HH. et al. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones.

J Transl Med 12 , Download citation. Received : 17 April Accepted : 01 August Published : 14 August Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search.

Download PDF. Abstract Background Breast cancer risk is partially determined by several hormone-related factors. Conclusion We conclude that among overweight and obese postmenopausal women, daily 1 gm dose of resveratrol has favorable effects on estrogen metabolism and SHBG.

Trial registration ClinicalTrials. Background Breast cancer risk is partially determined by several hormone-related factors, and it has long been hypothesized that high levels of endogenous hormones, especially estrogens, may increase breast cancer risk.

Methods Study design The study was an open label, single-arm intervention trial in postmenopausal women with high BMI. Study drugs Resveratrol drug product was supplied by Royalmount Pharma, Inc.

Study procedures During the initial visit, consented study subjects underwent medical history evaluation and had a fasting blood sample collected for complete blood count and comprehensive metabolic panel. Statistical analysis Descriptive statistics, e. Results Forty-six subjects were consented between June and March with six found to not meet all inclusion criteria.

Figure 1. Full size image. Discussion Overweight and obesity are associated with an increased risk for postmenopausal breast cancer and poor disease outcome reviewed by [ 26 ],[ 27 ].

Conclusions We conclude that in postmenopausal women with high BMI, daily 1 gm dose of resveratrol had favorable effects on SHBG and estrogen metabolites. Abbreviations BMI: Body mass index AE: Adverse events SHBG: Sex hormone binding globulin 2-OHE 1 : 2-hydroxyestrone 16α-OHE 1 : 16α-hydroxyestrone CYP: Cytochrome P References Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, Dossus L, Micheli A, Arslan A, Lenner P, Shore RE, Krogh V, Koenig KL, Riboli E, Berrino F, Hallmans G, Stattin P, Toniolo P, Kaaks R: Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein a cross-sectional study in healthy women.

Article CAS PubMed Google Scholar Boyapati SM, Shu XO, Gao YT, Dai Q, Yu H, Cheng JR, Jin F, Zheng W: Correlation of blood sex steroid hormones with body size, body fat distribution, and other known risk factors for breast cancer in post-menopausal Chinese women.

Article PubMed Google Scholar Kaye SA, Folsom AR, Soler JT, Prineas RJ, Potter JD: Associations of body mass and fat distribution with sex hormone concentrations in postmenopausal women. Article CAS PubMed Google Scholar Mahabir S, Baer DJ, Johnson LL, Hartman TJ, Dorgan JF, Campbell WS, Clevidence BA, Taylor PR: Usefulness of body mass index as a sufficient adiposity measurement for sex hormone concentration associations in postmenopausal women.

Article CAS PubMed Google Scholar Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE, Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Key TJ, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Muti P, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E: Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.

Article CAS PubMed Google Scholar Key T, Appleby P, Barnes I, Reeves G: Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. Article CAS PubMed Google Scholar Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR: Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding.

Article CAS PubMed Google Scholar Yue W, Santen RJ, Wang JP, Li Y, Verderame MF, Bocchinfuso WP, Korach KS, Devanesan P, Todorovic R, Rogan EG, Cavalieri EL: Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis.

Article CAS PubMed Google Scholar Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG: Estrogen metabolism and risk of breast cancer in postmenopausal women. Article PubMed Central CAS PubMed Google Scholar Serrero G, Lu R: Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells.

Article CAS PubMed Google Scholar Alkhalaf M: Resveratrol-induced growth inhibition in MDA-MB breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.

Article CAS PubMed Google Scholar Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM: Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.

CAS PubMed Google Scholar Wang Y, Lee KW, Chan FL, Chen S, Leung LK: The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Article CAS PubMed Google Scholar Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S: Anti-aromatase chemicals in red wine.

Article CAS PubMed Google Scholar Ciolino HP, Daschner PJ, Yeh GC: Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. CAS PubMed Google Scholar Yueh MF, Kawahara M, Raucy J: Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

Article CAS PubMed Google Scholar Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret JF, Casper RF: Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

Article CAS PubMed Google Scholar Piver B, Berthou F, Dreano Y, Lucas D: Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Article CAS PubMed Google Scholar Chang TK, Yeung RK: Effect of trans-resveratrol on 7-benzyloxytrifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5.

Article CAS PubMed Google Scholar Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS: Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.

Article CAS Google Scholar Tai SS, Welch MJ: Development and evaluation of a reference measurement procedure for the determination of estradiolbeta in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry. Article CAS PubMed Google Scholar Moal V, Mathieu E, Reynier P, Malthiery Y, Gallois Y: Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry.

Article CAS PubMed Google Scholar Boocock D, Patel KR, Faust GES, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP: Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.

Article PubMed Central PubMed Google Scholar Hunter DJ, Willett WC: Diet, body size, and breast cancer. CAS PubMed Google Scholar Stephenson GD, Rose DP: Breast cancer and obesity: an update. Article CAS PubMed Google Scholar Pugeat M, Nader N, Hogeveen K, Raverot G, Dechaud H, Grenot C: Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome.

Article CAS PubMed Google Scholar Sodergard R, Backstrom T, Shanbhag V, Carstensen H: Calculation of free and bound fractions of testosterone and estradiol beta to human plasma proteins at body temperature.

Article CAS PubMed Google Scholar Reed GA, Peterson KS, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A: A phase I study of indolecarbinol in women: tolerability and effects.

Article CAS PubMed Google Scholar Wong GY, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP: Dose-ranging study of indolecarbinol for breast cancer prevention. Article PubMed Google Scholar Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE: Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Article PubMed Central CAS PubMed Google Scholar Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N: Pilot study of resveratrol in older adults with impaired glucose tolerance.

Article PubMed Central PubMed Google Scholar Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, Rekabpour SJ, Netticadan T: Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients.

Article PubMed Central PubMed Google Scholar Download references. Acknowledgements The authors would like to acknowledge Wendy Thomas, Samantha Castro, and Steve Rodney for their excellent assistance in the clinical conduct of the study, Rebecca Weiner for her assistance in data analysis, and Dr.

Grant support This work was supported by a contract N01CN from the National Cancer Institute, Division of Cancer Prevention and the University of Arizona Cancer Center Support Grant CA from the National Cancer Institute.

View author publications. Additional information Competing interests The authors declare that they have no competing interests. Rights and permissions This article is published under license to BioMed Central Ltd. About this article. Cite this article Chow, HH.

Copy to clipboard. Journal of Translational Medicine ISSN: Contact us Submission enquiries: Access here and click Contact Us General enquiries: info biomedcentral.

Regular supplementation with low-dose resveratrol can enhance cognition, cerebrovascular function and insulin sensitivity in postmenopausal women. Zaw J. Clin Nutr. Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being.

Study has shown that supplementation with Resveratrol, improves with circulatory benefits, improves aspects of well-being including chronic pain, which is a common complaint in postmenopausal women.

These improvements are sustained by supplementation for at least 12 months and are associated with enhancement of circulatory function. Bone Health Resveratrol can act as a phytoestrogen. It has been shown to improve both systemic and cerebral circulatory functions.

Related products

For this reason, the scientific community is looking for innovative strategies to implement the bioavailability through drug delivery systems such as the use of nanoemulsion-based delivery systems [ 69 ] or through the ability to interact in a cooperative way with other molecules such as vitD.

However, the interplay between resveratrol and vitamin D must be further elucidated if the true potential of their clinical applications is to be revealed. In conclusion, this study demonstrated for the first time a cooperative effect of RES and vitD on ovarian cell and tissue, mediated by main physiological intracellular mechanisms.

Such results could be used as a fundamental data for the development of new therapies for gynecological conditions, such as menopause-related hot-flashes.

Bastin J, Djouadi F. Resveratrol and Myopathy. Waterhouse AL. Wine phenolics. Ann N Y Acad Sci. Article CAS PubMed Google Scholar.

Athar M, Back JH, Tang X, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol.

Article CAS PubMed PubMed Central Google Scholar. Yu M, Liu H, Shi A, et al. Preparation of resveratrol-enriched and poor allergic protein peanut sprout from ultrasound treated peanut seeds. Ultrason Sonochem. Harikumar KB, Aggarwal BB.

Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle. Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. Sessa M, Balestrieri ML, Ferrari G, et al. Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems.

Food Chem. Gambini J, Inglés M, Olaso G, et al. Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxidative Med Cell Longev.

Soleas GJ, Angelini M, Grass L, et al. Absorption of trans-resveratrol in rats. Methods Enzymol. Walle T, Hsieh F, DeLegge MH, et al.

High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem. Ramalingam P, Ko YT.

J Pharm Biomed Anal. Singh G, Pai RS. J Control Release. Summerlin N, Soo E, Thakur S, et al. Resveratrol nanoformulations: challenges and opportunities. Int J Pharm. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease.

Article Google Scholar. Tessitore L, Davit A, Sarotto I, et al. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21CIP expression. Li ZG, Hong T, Shimada Y, et al.

Suppression of N-nitrosomethylbenzylamine NMBA -induced esophageal tumorigenesis in F rats by resveratrol. Hambrock A, de Oliveira Franz CB, Hiller S, et al. Resveratrol binds to the sulfonylurea receptor SUR and induces apoptosis in a SUR subtype-specific manner.

J Biol Chem. Bowers JL, Tyulmenkov VV, Jernigan SC, et al. Nwachukwu JC, Srinivasan S, Bruno NE, et al.

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Schmitt E, Lehmann L, Metzler M, et al.

Hormonal and genotoxic activity of resveratrol. Toxicol Lett. Klinge CM, Blankenship KA, Risinger KE, et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. Saleh MC, Connell BJ, Saleh TM. Resveratrol induced neuroprotection is mediated via both estrogen receptor subtypes, ER α and ER β.

Neurosci Lett. Leo L, Surico D, Deambrogio F, et al. Minerva Ginecol. CAS PubMed Google Scholar. Nwachukwu JC, Li W, Pineda-Torra I, et al. Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone Mol Endocrinol.

Nwachukwu JC, Southern MR, Kiefer JR, et al. Improved crystallographic structures using extensive combinatorial refinement. Thill M, Fischer D, Kelling K, et al.

Expression of vitamin D receptor VDR , cyclooxygenase-2 COX-2 and hydroxyprostaglandin dehydrogenase PGDH in benign and malignant ovarian tissue and hydroxycholecalciferol 25 OH2 D3 and prostaglandin E2 PGE2 serum level in ovarian cancer patients.

J Steroid Biochem Mol Biol. Uberti F, Morsanuto V, Lattuada D, et al. Protective effects of vitamin D3 on fimbrial cells exposed to catalytic iron damage. J Ovarian Res.

Dampf Stone A, Batie SF, Sabir MS, et al. Resveratrol potentiates vitamin D and nuclear receptor signaling. J Cell Biochem. Bartik L, Whitfield GK, Kaczmarska M, et al. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

J Nutr Biochem. Davis CD, Milner JA. Nutrigenomics, vitamin D and cancer prevention. J Nutrigenet Nutrigenomics. Jurutka PW, Whitfield GK, Forster R, et al. Vitamin D: a fountain of youth in gene regulation. In: Gombart AF, editor. Vitamin D:oxidative stress, immunity, and aging. Boca Raton: CRC Press; Google Scholar.

Guo C, Sinnott B, Niu B, et al. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Li H, Xia N, Forstermann U. Cardiovascular effects and molecular targets of resveratrol.

Nitric Oxide. Article PubMed Google Scholar. Hii CS, Ferrante A. The non-genomic actions of vitamin D.

Mallebrera B, Brandolini V, Font G, et al. Cytoprotective effect of resveratrol diastereomers in CHO-K1 cells exposed to beauvericin. Food Chem Toxicol. Ortega I, Wong DH, Villanueva JA, et al. Effects of resveratrol on growth and function of rat ovarian granulosa cells.

Fertil Steril. Tomé-Carneiro J, Larrosa M, González-Sarrías A, et al. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des. Article PubMed PubMed Central Google Scholar. Miyashita M, Koga K, Izumi G, et al. Effects of 1,Dihydroxy vitamin D3 on endometriosis.

J Clin Endocrinol Metab. Uberti F, Bardelli C, Morsanuto V, et al. Role of vitamin D3 combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells.

BMC Gastroenterol. Uberti F, Lattuada D, Morsanuto V, et al. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. Uberti F, Morsanuto V, Bardelli C, et al. Protective effects of 1α,Dihydroxyvitamin D3 on cultured neural cells exposed to catalytic iron.

Physiol Rep. Bonnichsen M, Dragsted N, Hansen AK. The welfare impact of gavaging laboratory rats. Anim Welf. CAS Google Scholar. Turner PV, Vaughn E, Sunohara-Neilson J, et al.

Oral gavage in rats: animal welfare evaluation. J Am Assoc Lab Anim Sci. CAS PubMed PubMed Central Google Scholar. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited.

FASEB J. Kampa M, Nistikaki A, Tsaousis V, et al. A new automated method for the determination of the total antioxidant capacity TAC of human plasma, based on the crocin bleaching assay.

BMC Clin Pathol. Conte A, Pellegrini S, Tagliazucchi D. Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity. Drugs Exp Clin Res. Li Q, Huyan T, Ye LJ, et al.

Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro. J Agric Food Chem. Ortega I, Villanueva JA, Wong DH, et al. Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis.

Ortega I, Duleba AJ. Ovarian actions of resveratrol. Morita Y, Wada-Hiraike O, Yano T, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.

Reprod Biol Endocrinol. Henry LA, Witt DM. Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats. Horm Behav. Fulda S, Debatin KM. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review.

Cancer Detect Prev. Brito PM, Mariano A, Almeida LM, et al. Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: a role for intracellular glutathione. Chem Biol Interact. Gong QH, Wang Q, Shi JS, et al. Acta Pharmacol Sin.

Anekonda TS, Adamus G. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku BMC Res Notes. Cao C, Lu S, Kivlin R, et al. After 12 months of supplementation with resveratrol versus placebo, there were positive effects on bone density.

This sub analysis reveals that the bone-protective benefit of resveratrol was greater in participants who supplemented with vitamin D plus calcium. Regular supplementation with 75 mg of resveratrol twice daily has the potential to slow bone loss.

Wong R. J Bone Miner Res. Women 65 years of age showed a relative improvement in verbal memory with resveratrol compared to those younger than 65 years. This may translate into a slowing of the accelerated cognitive decline due to ageing and menopause, especially in late-life women.

Further studies are warranted to observe whether these cognitive benefits of resveratrol can reduce the risk of dementia. More importantly, the research team confirmed the benefits of resveratrol as being sustained over a period of time. The authors explain that estrogen deprivation can accelerate age-related arterial stiffening and impair tissue perfusion by reducing endothelium-dependent vasodilatation, noting that this increases the risk of dementia and cerebrovascular diseases, which are emerging as the leading causes of death in older women.

These differences can be partly attributed to the rapid mid-life decline in circulating estrogen following menopause. Estrogen is important for memory retention, metabolic regulation and bone health in pre-menopausal women. Hence, the loss of estrogen may accelerate age-related cognitive impairment and increase the risk of cardiovascular and cerebrovascular diseases.

The report goes on to point out that dementia mortality rates in women in were almost twice that of men. Resveratrol could be helpful to those experiencing cognitive issues that are not menopause-related, said da Silva Pinto.

Da Silva Pinto told NutraIngredients-USA that having science to back Evolva's products is critical. That is why Evolva supports several ongoing research projects with Veri-te resveratrol.

At the moment, Veri-te has been included in 13 clinical studies with esteemed universities and third-party researchers. She added that Evolva has a number of studies in various phases, with some in recruiting stages, others underway and a couple awaiting publication.

Zaw et al.

Biological effects of combined resveratrol and vitamin D3 on ovarian tissue

Sodergard R, Backstrom T, Shanbhag V, Carstensen H: Calculation of free and bound fractions of testosterone and estradiol beta to human plasma proteins at body temperature. J Steroid Biochem.

Reed GA, Peterson KS, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A: A phase I study of indolecarbinol in women: tolerability and effects. Wong GY, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP: Dose-ranging study of indolecarbinol for breast cancer prevention.

J Cell Biochem Suppl. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE: Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N: Pilot study of resveratrol in older adults with impaired glucose tolerance.

J Gerontol A Biol Sci Med Sci. Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, Rekabpour SJ, Netticadan T: Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients.

Evid Based Complement Alternat Med. Download references. The authors would like to acknowledge Wendy Thomas, Samantha Castro, and Steve Rodney for their excellent assistance in the clinical conduct of the study, Rebecca Weiner for her assistance in data analysis, and Dr.

Karen Hastings for serving as the Medical Director of the study in the greater Phoenix area. This work was supported by a contract N01CN from the National Cancer Institute, Division of Cancer Prevention and the University of Arizona Cancer Center Support Grant CA from the National Cancer Institute.

University of Arizona Cancer Center, N Campbell Ave, Tucson, , AZ, USA. Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. You can also search for this author in PubMed Google Scholar.

Correspondence to H-H Sherry Chow. SC conceived the study, participated in its design and coordination, data interpretation, and manuscript preparation, LG participated in the study design and data interpretation and served as the study physician, BH coordinated the study agent acquisition and participated in the study design and data interpretation, CH participated in the study design and performed the statistical analysis, VB coordinated the participant recruitment and study conduct, CC coordinated the specimen management and carried out the biomarker analysis, WC carried out the biomarker analysis, TC participated in the study design and data interpretation and served as the medical monitor for the study.

All authors provided feedback to the manuscript. All authors read and approved the final manuscript. This article is published under license to BioMed Central Ltd. Reprints and permissions. Chow, HH. et al.

A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12 , Download citation.

Received : 17 April Accepted : 01 August Published : 14 August Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF.

Abstract Background Breast cancer risk is partially determined by several hormone-related factors. Conclusion We conclude that among overweight and obese postmenopausal women, daily 1 gm dose of resveratrol has favorable effects on estrogen metabolism and SHBG.

Trial registration ClinicalTrials. Background Breast cancer risk is partially determined by several hormone-related factors, and it has long been hypothesized that high levels of endogenous hormones, especially estrogens, may increase breast cancer risk.

Methods Study design The study was an open label, single-arm intervention trial in postmenopausal women with high BMI. Study drugs Resveratrol drug product was supplied by Royalmount Pharma, Inc.

Study procedures During the initial visit, consented study subjects underwent medical history evaluation and had a fasting blood sample collected for complete blood count and comprehensive metabolic panel. Statistical analysis Descriptive statistics, e. Results Forty-six subjects were consented between June and March with six found to not meet all inclusion criteria.

Figure 1. Full size image. Discussion Overweight and obesity are associated with an increased risk for postmenopausal breast cancer and poor disease outcome reviewed by [ 26 ],[ 27 ].

Conclusions We conclude that in postmenopausal women with high BMI, daily 1 gm dose of resveratrol had favorable effects on SHBG and estrogen metabolites. Abbreviations BMI: Body mass index AE: Adverse events SHBG: Sex hormone binding globulin 2-OHE 1 : 2-hydroxyestrone 16α-OHE 1 : 16α-hydroxyestrone CYP: Cytochrome P References Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, Dossus L, Micheli A, Arslan A, Lenner P, Shore RE, Krogh V, Koenig KL, Riboli E, Berrino F, Hallmans G, Stattin P, Toniolo P, Kaaks R: Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein a cross-sectional study in healthy women.

Article CAS PubMed Google Scholar Boyapati SM, Shu XO, Gao YT, Dai Q, Yu H, Cheng JR, Jin F, Zheng W: Correlation of blood sex steroid hormones with body size, body fat distribution, and other known risk factors for breast cancer in post-menopausal Chinese women.

Article PubMed Google Scholar Kaye SA, Folsom AR, Soler JT, Prineas RJ, Potter JD: Associations of body mass and fat distribution with sex hormone concentrations in postmenopausal women.

Article CAS PubMed Google Scholar Mahabir S, Baer DJ, Johnson LL, Hartman TJ, Dorgan JF, Campbell WS, Clevidence BA, Taylor PR: Usefulness of body mass index as a sufficient adiposity measurement for sex hormone concentration associations in postmenopausal women. Article CAS PubMed Google Scholar Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE, Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Key TJ, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Muti P, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E: Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.

Article CAS PubMed Google Scholar Key T, Appleby P, Barnes I, Reeves G: Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. Article CAS PubMed Google Scholar Zhu BT, Han GZ, Shim JY, Wen Y, Jiang XR: Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding.

Article CAS PubMed Google Scholar Yue W, Santen RJ, Wang JP, Li Y, Verderame MF, Bocchinfuso WP, Korach KS, Devanesan P, Todorovic R, Rogan EG, Cavalieri EL: Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis.

Article CAS PubMed Google Scholar Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, Buys SS, Isaacs C, Keefer LK, Veenstra TD, Berg CD, Hoover RN, Ziegler RG: Estrogen metabolism and risk of breast cancer in postmenopausal women.

Article PubMed Central CAS PubMed Google Scholar Serrero G, Lu R: Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Article CAS PubMed Google Scholar Alkhalaf M: Resveratrol-induced growth inhibition in MDA-MB breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.

Article CAS PubMed Google Scholar Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM: Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. CAS PubMed Google Scholar Wang Y, Lee KW, Chan FL, Chen S, Leung LK: The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.

Article CAS PubMed Google Scholar Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S: Anti-aromatase chemicals in red wine. Article CAS PubMed Google Scholar Ciolino HP, Daschner PJ, Yeh GC: Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor.

CAS PubMed Google Scholar Yueh MF, Kawahara M, Raucy J: Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Article CAS PubMed Google Scholar Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret JF, Casper RF: Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

Article CAS PubMed Google Scholar Piver B, Berthou F, Dreano Y, Lucas D: Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.

Article CAS PubMed Google Scholar Chang TK, Yeung RK: Effect of trans-resveratrol on 7-benzyloxytrifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. Article CAS PubMed Google Scholar Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS: Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.

Article CAS Google Scholar Tai SS, Welch MJ: Development and evaluation of a reference measurement procedure for the determination of estradiolbeta in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry.

Article CAS PubMed Google Scholar Moal V, Mathieu E, Reynier P, Malthiery Y, Gallois Y: Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry.

Article CAS PubMed Google Scholar Boocock D, Patel KR, Faust GES, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP: Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.

Article PubMed Central PubMed Google Scholar Hunter DJ, Willett WC: Diet, body size, and breast cancer. CAS PubMed Google Scholar Stephenson GD, Rose DP: Breast cancer and obesity: an update.

Article CAS PubMed Google Scholar Pugeat M, Nader N, Hogeveen K, Raverot G, Dechaud H, Grenot C: Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome.

Article CAS PubMed Google Scholar Sodergard R, Backstrom T, Shanbhag V, Carstensen H: Calculation of free and bound fractions of testosterone and estradiol beta to human plasma proteins at body temperature. Article CAS PubMed Google Scholar Reed GA, Peterson KS, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A: A phase I study of indolecarbinol in women: tolerability and effects.

Article CAS PubMed Google Scholar Wong GY, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP: Dose-ranging study of indolecarbinol for breast cancer prevention. Article PubMed Google Scholar Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE: Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Article PubMed Central CAS PubMed Google Scholar Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N: Pilot study of resveratrol in older adults with impaired glucose tolerance. Article PubMed Central PubMed Google Scholar Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, Rekabpour SJ, Netticadan T: Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients.

Article PubMed Central PubMed Google Scholar Download references. Acknowledgements The authors would like to acknowledge Wendy Thomas, Samantha Castro, and Steve Rodney for their excellent assistance in the clinical conduct of the study, Rebecca Weiner for her assistance in data analysis, and Dr.

Grant support This work was supported by a contract N01CN from the National Cancer Institute, Division of Cancer Prevention and the University of Arizona Cancer Center Support Grant CA from the National Cancer Institute.

View author publications. Additional information Competing interests The authors declare that they have no competing interests. Rights and permissions This article is published under license to BioMed Central Ltd.

Bottom Line Health. Breast Cancer Colon Cancer Prostate Cancer Skin Cancer. Diseases and Conditions. Digestive Respiratory Stroke. Personal Finances. Estate Planning Loans Medical Expenses Real Estate.

Mutual Funds and ETFs Portfolio Strategy Stocks. Retirement Planning. Retirement Accounts Retirement Living. Cutting Taxes Tax Planning Tax Preparation. Automotive Consumer Technology Home Travel. Bottom Line Personal Subscription Bottom Line Health Subscription.

Bottom Line Yearbook Bottom Line Health Breakthroughs Women's Guide to Beating Disease. explore Supplements. Clinical trial registration: ACTRNp. Abstract Objective: Following concerns about hormone therapy, postmenopausal women need alternative options to manage menopause-related symptoms and improve their well-being.

Publication types Randomized Controlled Trial. Substances Resveratrol.

Resveratrol and menopause -

Women 65 years of age showed a relative improvement in verbal memory with resveratrol compared to those younger than 65 years. This may translate into a slowing of the accelerated cognitive decline due to ageing and menopause, especially in late-life women.

Further studies are warranted to observe whether these cognitive benefits of resveratrol can reduce the risk of dementia. More importantly, the research team confirmed the benefits of resveratrol as being sustained over a period of time. The authors explain that estrogen deprivation can accelerate age-related arterial stiffening and impair tissue perfusion by reducing endothelium-dependent vasodilatation, noting that this increases the risk of dementia and cerebrovascular diseases, which are emerging as the leading causes of death in older women.

These differences can be partly attributed to the rapid mid-life decline in circulating estrogen following menopause. Estrogen is important for memory retention, metabolic regulation and bone health in pre-menopausal women.

Hence, the loss of estrogen may accelerate age-related cognitive impairment and increase the risk of cardiovascular and cerebrovascular diseases. The report goes on to point out that dementia mortality rates in women in were almost twice that of men.

Resveratrol could be helpful to those experiencing cognitive issues that are not menopause-related, said da Silva Pinto. Da Silva Pinto told NutraIngredients-USA that having science to back Evolva's products is critical. That is why Evolva supports several ongoing research projects with Veri-te resveratrol.

At the moment, Veri-te has been included in 13 clinical studies with esteemed universities and third-party researchers. She added that Evolva has a number of studies in various phases, with some in recruiting stages, others underway and a couple awaiting publication.

Zaw et al. Expression of vitamin D receptor VDR , cyclooxygenase-2 COX-2 and hydroxyprostaglandin dehydrogenase PGDH in benign and malignant ovarian tissue and hydroxycholecalciferol 25 OH2 D3 and prostaglandin E2 PGE2 serum level in ovarian cancer patients.

J Steroid Biochem Mol Biol. Uberti F, Morsanuto V, Lattuada D, et al. Protective effects of vitamin D3 on fimbrial cells exposed to catalytic iron damage. J Ovarian Res. Dampf Stone A, Batie SF, Sabir MS, et al. Resveratrol potentiates vitamin D and nuclear receptor signaling. J Cell Biochem.

Bartik L, Whitfield GK, Kaczmarska M, et al. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

J Nutr Biochem. Davis CD, Milner JA. Nutrigenomics, vitamin D and cancer prevention. J Nutrigenet Nutrigenomics. Jurutka PW, Whitfield GK, Forster R, et al. Vitamin D: a fountain of youth in gene regulation.

In: Gombart AF, editor. Vitamin D:oxidative stress, immunity, and aging. Boca Raton: CRC Press; Google Scholar. Guo C, Sinnott B, Niu B, et al.

Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Li H, Xia N, Forstermann U. Cardiovascular effects and molecular targets of resveratrol.

Nitric Oxide. Article PubMed Google Scholar. Hii CS, Ferrante A. The non-genomic actions of vitamin D. Mallebrera B, Brandolini V, Font G, et al. Cytoprotective effect of resveratrol diastereomers in CHO-K1 cells exposed to beauvericin. Food Chem Toxicol. Ortega I, Wong DH, Villanueva JA, et al.

Effects of resveratrol on growth and function of rat ovarian granulosa cells. Fertil Steril. Tomé-Carneiro J, Larrosa M, González-Sarrías A, et al.

Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des. Article PubMed PubMed Central Google Scholar. Miyashita M, Koga K, Izumi G, et al. Effects of 1,Dihydroxy vitamin D3 on endometriosis.

J Clin Endocrinol Metab. Uberti F, Bardelli C, Morsanuto V, et al. Role of vitamin D3 combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells.

BMC Gastroenterol. Uberti F, Lattuada D, Morsanuto V, et al. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. Uberti F, Morsanuto V, Bardelli C, et al. Protective effects of 1α,Dihydroxyvitamin D3 on cultured neural cells exposed to catalytic iron.

Physiol Rep. Bonnichsen M, Dragsted N, Hansen AK. The welfare impact of gavaging laboratory rats. Anim Welf. CAS Google Scholar. Turner PV, Vaughn E, Sunohara-Neilson J, et al. Oral gavage in rats: animal welfare evaluation. J Am Assoc Lab Anim Sci.

CAS PubMed PubMed Central Google Scholar. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. Kampa M, Nistikaki A, Tsaousis V, et al. A new automated method for the determination of the total antioxidant capacity TAC of human plasma, based on the crocin bleaching assay.

BMC Clin Pathol. Conte A, Pellegrini S, Tagliazucchi D. Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity. Drugs Exp Clin Res. Li Q, Huyan T, Ye LJ, et al. Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro.

J Agric Food Chem. Ortega I, Villanueva JA, Wong DH, et al. Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. Ortega I, Duleba AJ.

Ovarian actions of resveratrol. Morita Y, Wada-Hiraike O, Yano T, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reprod Biol Endocrinol.

Henry LA, Witt DM. Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats. Horm Behav. Fulda S, Debatin KM. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Cancer Detect Prev. Brito PM, Mariano A, Almeida LM, et al.

Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: a role for intracellular glutathione. Chem Biol Interact. Gong QH, Wang Q, Shi JS, et al. Acta Pharmacol Sin. Anekonda TS, Adamus G. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku BMC Res Notes.

Cao C, Lu S, Kivlin R, et al. SIRT1 confers protection against UVB- and H 2 O 2 -induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J Cell Mol Med. Rubiolo JA, Mithieux G, Vega FV. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes.

Eur J Pharmacol. Shin SM, Cho IJ, Kim SG. Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly ADP-ribose polymerase-LKB1 pathway.

Mol Pharmacol. Wong DH, Villanueva JA, Cress AB, et al. Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells. Mol Hum Reprod. Donesky BW, Adashi EY. Surgically induced ovulation in the polycystic ovary syndrome: wedge resection revisited in the age of laparoscopy.

Duleba AJ, Banaszewska B, Spaczynski RZ, et al. Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels.

Meng X, Maliakal P, Lu H, et al. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice.

Baber R. The hot flush: symptom of menopause or sign of disease? Lethaby AE, Brown J, Marjoribanks J, et al.

Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev. Update in: Cochrane Database Syst Rev. Davinelli S, Scapagnini G, Marzatico F, et al. Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: a randomized, placebo-controlled study.

Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Delmas D, Aires V, Limagne E, et al. Transport, stability, and biological activity of resveratrol. Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, et al.

Resveratrol bioavailability and toxicity in humans. Download references. Any source of funding to declare. The authors sincerely thank Ms. Mariangela Fortunato for her precious help in revising the article. Physiology Laboratory, Department of Translational Medicine, UPO, Via Solaroli, 17 , Novara, Italy.

Department of Pharmaceutical Sciences and Drug and Food Biotechnology Center, UPO, Novara, Italy. Department of Health Sciences, Medical School, UPO, Novara, Italy.

You can also search for this author in PubMed Google Scholar. designed the study and wrote the manuscript; F. performed the in vitro experiments; F.

performed the in vivo experiments; S. performed the RES quantification in cells and tissues; F. and C. analyzed the data; G. supervised the manuscript. All authors read and approved the final manuscript.

Correspondence to Francesca Uberti. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Additional details about RES quantification using HPLC-MS in cells and plasma samples.

DOCX 69 kb. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Uberti, F. et al. Biological effects of combined resveratrol and vitamin D3 on ovarian tissue. J Ovarian Res 10 , 61 Download citation.

Received : 09 June Accepted : 05 September Published : 15 September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Methods The experiments were performed both in vitro and in vivo, to analyze cell viability, radical oxygen species production, signal transductions through Western Blot, and resveratrol quantification by HPLC.

Results Cell viability, radical oxygen species production, and intracellular pathways have been studied on CHO-K1 cells.

Conclusions Such results could be used as a fundamental data for the development of new therapies for gynecological conditions, such as hot-flashes.

MTT test MTT-based In Vitro Toxicology Assay Kit Sigma-Aldrich was performed as described in literature [ 40 ] to determine cell viability after stimulations. ROS production The rate of superoxide anion production was determined as a superoxide dismutase-inhibitable reduction of cytochrome C, following a standard technique [ 41 , 42 ].

Western blot of cell lysates CHO-K1 cells were lysed in ice Complete Tablet Buffer Roche supplemented with 2 mM sodium orthovanadate, 1 mM phenylmethanesulfonyl fluoride PMSF; Sigma-Aldrich , mix Phosphatase Inhibitor Cocktail Sigma-Aldrich and mix Protease Inhibitor Cocktail Calbiochem. In vivo experimental protocol In order to study the bioavailability 0.

Plasma vitamin D quantification Vitamin D3, the active form of vitamin D, is very short-lived and rapidly metabolized to the deactivated forms 24,25 OH 2D3 and 1,24,25 OH 3D3.

Content provided by Verdure Sciences Feb White Paper. Cognitive health, mental acuity and brain support categories have seen tremendous growth. With an aging population and increased interest from formulators Content provided by Natural Remedies Private Limited Jan White Paper.

More than ever, stress is extremely common among adults today. CONTINUE TO SITE Or wait Findings Resveratrol supplementation was found to reduce composite pain score, especially in overweight individuals; this was associated with improvements in cerebrovascular responsiveness to hypercapnia. Zaw et al.

Consumers' growing demand for Omegas Content provided by Fruit d'Or Feb White Paper Consumers are increasingly interested in the benefits of omegas supplements. Innovation in Stress and Sleep Management: Holixer Content provided by Natural Remedies Private Limited Jan White Paper More than ever, stress is extremely common among adults today.

Objective: Following concerns nenopause hormone Resverarrol, postmenopausal women need Weekly meal planner options to manage menopause-related symptoms Resveratrol and menopause improve their well-being. A week pilot Resvefatrol has annd that Rexveratrol with resveratrol, a phytoestrogen with circulatory benefits, can improve aspects of well-being including chronic pain, which is a menopausse complaint in postmenopausal Anti-aging superfood supplement. We menopauze Resveratrol and menopause menopaude these benefits in a larger, long-term study. Methods: The Resveratrol for Healthy Ageing in Women study, a month randomized, double-blind, placebo-controlled, two-period crossover intervention trial of resveratrol supplementation 75 mg BID was conducted in healthy postmenopausal women to evaluate effects on cognitive performance results published elsewhere. Aspects of well-being including pain perception, mood and depressive symptoms, menopausal symptoms, sleep quality, and quality of life were assessed with questionnaires as secondary outcomes of the study. Cerebrovascular responsiveness to hypercapnia was measured as a surrogate marker of cerebrovascular function. Conclusions: These results confirm the pilot study finding that resveratrol supplementation can reduce chronic pain in age-related osteoarthritis and improve menopause-related quality of life in postmenopausal women. Resveratrol and menopause

Video

Menopausal hormone therapy and reduction of all cause mortality.

Author: Maut

2 thoughts on “Resveratrol and menopause

Leave a comment

Yours email will be published. Important fields a marked *

Design by ThemesDNA.com